Evidence map›Paper›PMID 31941814›Full record

ArticlemSphere2020

Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Regulate Maturation of the Cyst Wall.

Rebekah B Guevara, Barbara A Fox, David J Bzik

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Dense granule proteins: key mediators ofFrontiers in medicine · 2026
    Review
  4. Article
  5. Article
  6. The Distribution ofMicroorganisms · 2025
    Article
  7. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Frontiers in immunology · 2023
    Article
  13. Article
  14. The determinants regulatingFrontiers in microbiology · 2022
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rebekah B GuevaraDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Barbara A FoxDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
David J BzikDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA david.j.bzik@dartmouth.edu.
Dartmouth College · US

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5M
HOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9M
Geographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1M
Genetic models for latent Toxoplasma gondii infectionR21AI137118 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2018 to 2019
$446k
Novel virulence function in Toxoplasma chronic infectionR21AI131630 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2018 to 2019
$446k
Dense granule protein virulence factors in Toxoplasma gondii infectionR21AI108489 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2014 to 2015
$446k
Toxoplasma gondii GRA protein functionR21AI105563 · NIAID · DARTMOUTH COLLEGE · PI BZIK, DAVID J · 2013 to 2014
$433k
NIAID NIH HHS R21 AI105563NIAID NIH HHS R21 AI108489NIAID NIH HHS R21 AI131630NIAID NIH HHS R21 AI137118NIAID NIH HHS T32 AI007363NIAID NIH HHS T32 AI007519NIAID NIH HHS T32 AI070117NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

After differentiation is triggered, the tachyzoite-stage

Indexed as

Antigens, ProtozoanCell WallGene DeletionGene Expression RegulationProtozoan ProteinsToxoplasmaVacuolesAntigens, ProtozoanGRA5 protein, Toxoplasma gondiiGRA7 protein, Toxoplasma gondiiProtozoan Proteinsbradyzoite differentiationchronic infectioncyst developmentcyst membranecystscyst walldense granulesGRAparasitophorous vacuole membraneToxoplasma gondii

Identifiers

PMID31941814
PMCPMC6968655
OpenAlexW3000735721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.