Evidence map›Paper›PMID 31941790›Full record

ArticleThe Journal of biological chemistry2020

A novel peptide exerts potent immunosuppression by blocking the two-site interaction of NFAT with calcineurin.

Lu Wang, Na Cheng, Ping Wang, Jing Li, Anna Jia, Wenying Li, Nan Zhang, Yanxia Yin, Li Tong, Qun Wei and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. A polypeptide inhibitor of calcineurin blocks the calcineurin-NFAT signalling pathwayJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  5. Yeast as a Model to Find New Drugs and Drug Targets forInternational journal of molecular sciences · 2022
    Review
  6. Peptide Biomaterials for Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2022
    Review
  7. Article
  8. Article
  9. AKAP Signaling Islands: Venues for Precision Pharmacology.Trends in pharmacological sciences · 2020
    Review
  10. Calcineurin.Cell communication and signaling : CCS · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Lu WangDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Na ChengDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Ping WangDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Jing LiDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Anna JiaDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Wenying LiDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Nan ZhangDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Yanxia YinDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Li TongDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Qun WeiDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Guangwei LiuDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Zhimei LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing 100050, China. Electronic address: lizm1211@163.com.
Jing LuoDepartment of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology of Beijing Key Laboratory, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China. Electronic address: luojing@bnu.edu.cn.
Beijing Normal University · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The calcineurin/nuclear factor of activated T cell (CN/NFAT) signaling pathway plays a critical role in the immune response. Therefore, inhibition of the CN/NFAT pathway is an important target for inflammatory disease. The conserved P

Indexed as

Amino Acid MotifsAnimalsBinding SitesCalcineurinHumansImmunosuppression TherapyImmunosuppressive AgentsInflammationNFATC Transcription FactorsPeptidesProtein BindingSignal TransductionCalcineurinImmunosuppressive AgentsNFATC Transcription FactorsPeptidescalcineurincellular immune responsecytokineenzyme inhibitorNFAT transcription factor

Identifiers

PMID31941790
PMCPMC7049967
OpenAlexW2999177960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.