Evidence map›Paper›PMID 31941754›Full record

ArticleMolecular cancer research : MCR2020

AGO2 Mediates

Kai Zhang, Yotsawat Pomyen, Anna E Barry, Sean P Martin, Subreen Khatib, Lucy Knight, Marshonna Forgues, Dana A Dominguez, Ravinder Parhar, Ashesh P Shah and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. mArXiv · 2026
    Article
  2. The AGO2-ATOX1 axis exacerbates inflammation in a mouse sepsis model.Central-European journal of immunology · 2026
    Article
  3. Article
  4. Article
  5. MYC: The Guardian of Its Own Chaos.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  6. Article
  7. MYC function and regulation in physiological perspective.Frontiers in cell and developmental biology · 2023
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Kai ZhangDepartment of Surgery, Department of Surgical Research, Thomas Jefferson University, Philadelphia, Pennsylvania.
Yotsawat PomyenLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.ORCID 0000-0002-1070-3047
Anna E BarryDepartment of Surgery, Department of Surgical Research, Thomas Jefferson University, Philadelphia, Pennsylvania.ORCID 0000-0001-8597-8881
Sean P MartinLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.ORCID 0000-0002-6923-947X
Subreen KhatibLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Lucy KnightLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Marshonna ForguesLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Dana A DominguezLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Ravinder ParharLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Ashesh P ShahDepartment of Surgery, Department of Surgical Research, Thomas Jefferson University, Philadelphia, Pennsylvania.ORCID 0000-0001-9286-4161
Adam S BodzinDepartment of Surgery, Department of Surgical Research, Thomas Jefferson University, Philadelphia, Pennsylvania.
Xin Wei WangLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. hien.dang@jefferson.edu xw3u@nih.gov.ORCID 0000-0001-9735-606X
Hien DangDepartment of Surgery, Department of Surgical Research, Thomas Jefferson University, Philadelphia, Pennsylvania. hien.dang@jefferson.edu xw3u@nih.gov.
National Cancer Institute · USThomas Jefferson University · USChulabhorn Research Institute · TH

Funding

Strategies for improving early detection, diagnosis and treatment of liver cancerZIABC010313 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, XIN WEI · 2009 to 2025
$18.1M
Molecular signatures for liver cancer diagnosis and treatment stratificationZ01BC010313 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, XIN WEI · 1999 to 2008
$1.8M
The role of cancer stem cells in liver cancer heterogeneity and subtypesZ01BC010876 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, XIN · 2008 to 2008
$490k
The identification of human hepatocellular carcinoma metastasis genesZ01BC010877 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, XIN · 2008 to 2008
$327k
Intramural NIH HHS Z01 BC010313Intramural NIH HHS Z01 BC010876Intramural NIH HHS Z01 BC010877
6 · The paper itself

Abstract

Deregulated RNA-binding proteins (RBP), such as Argonaute 2 (AGO2), mediate tumor-promoting transcriptomic changes during carcinogenesis, including hepatocellular carcinoma (HCC). While AGO2 is well characterized as a member of the RNA-induced silencing complex (RISC), which represses gene expression through miRNAs, its role as a bona fide RBP remains unclear. In this study, we investigated AGO2's role as an RBP that regulates the

Indexed as

Genes, mycAnimalsArgonaute ProteinsCarcinoma, HepatocellularCell Line, TumorHeterograftsHumansLiver NeoplasmsMiceMice, Inbred NODMice, NudeMice, SCIDProto-Oncogene Proteins c-mycRNA, MessengerTransfectionAGO2 protein, humanArgonaute ProteinsMYC protein, humanProto-Oncogene Proteins c-mycRNA, Messenger

Identifiers

PMID31941754
PMCPMC7127970
OpenAlexW2998964213

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.