ArticleClinical medicine (London, England)2020
Cardiovascular prevention: Frontiers in lipid guidelines.
Article in Clinical medicine (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Postnatal Cardiometabolic Health After Metformin Use in Gestational Diabetes: A Secondary Analysis of the EMERGE Trial.The Journal of clinical endocrinology and metabolism · 2025Article
- Intensifying approaches to address clinical inertia among cardiovascular disease risk factors: A narrative review.Patient education and counseling · 2022Review
- Relationship of low-density lipoprotein-cholesterol and lipoprotein(a) to cardiovascular risk: The Multi-Ethnic Study of Atherosclerosis (MESA).Atherosclerosis · 2022Article
- Cardiovascular risk management in people with type 1 diabetes: performance using three guidelines.BMJ open diabetes research & care · 2022Article
- The history of proprotein convertase subtilisin kexin-9 inhibitors and their role in the treatment of cardiovascular disease.Therapeutic advances in chronic disease · 2020Review
- Effects ofFrontiers in microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease (CVD) remains one of the principal causes of morbidity and mortality in the world. International guidelines are being updated to take into account new evidence and improved health economics as drug patents expire. Recent studies have investigated the best lipid fractions to predict CVD, suggested additional CVD risk factors and a potential role for novel biomarkers while big data approaches have allowed improvements to be made to CVD risk calculators. The increasing availability of next generation sequencing is allowing systematic efforts to be made to detect monogenic familial hypercholesterolaemia.Previous trials have validated the low-density lipoprotein cholesterol (LDL-C) hypothesis of atherosclerosis. Statins now form part of universal treatment advice for CVD and trial data on ezetimibe also suggests it has a place in the treatment pathway. New data has been published on novel lipid-lowering therapies such as proprotein convertase subtilisin kexin 9 inhibitors but the role of these expensive drugs has yet to be fully settled and a diversity of approaches exists between guidelines.The role of lipid fractions outside LDL-C is unclear. There will be challenges in incorporating new non-linear data on omega-3 fatty acids that not only affect triglycerides but more directly CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.