Evidence map›Paper›PMID 31941717›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2020

Cannabinoid Modulation of Food-Cocaine Choice in Male Rhesus Monkeys.

William S John, Thomas J Martin, Michael A Nader

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

William S JohnDepartments of Physiology and Pharmacology (W.S.J., M.A.N.) and Anesthesiology (T.J.M.), Wake Forest School of Medicine, Winston-Salem, North Carolina.
Thomas J MartinDepartments of Physiology and Pharmacology (W.S.J., M.A.N.) and Anesthesiology (T.J.M.), Wake Forest School of Medicine, Winston-Salem, North Carolina.
Michael A NaderDepartments of Physiology and Pharmacology (W.S.J., M.A.N.) and Anesthesiology (T.J.M.), Wake Forest School of Medicine, Winston-Salem, North Carolina mnader@wakehealth.edu.
Wake Forest University · US

Funding

TROPANE EVALUATION AND GENERAL SCIENTIFIC SERVICES COREP50DA006634 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NADER, MICHAEL A · 1991 to 2019
$30.8M
Behavioral and pharmacological determinants of cannabinoid reinforcement and effects on cognition in rhesus monkeysF31DA041825 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JOHN, WILLIAM SCOTT · 2016 to 2016
$33k
NIDA NIH HHS F31 DA041825NIDA NIH HHS P50 DA006634
6 · The paper itself

Abstract

Marijuana and other cannabinoid compounds are widely used by cocaine users. Preclinical animal studies suggest that these compounds can increase the reinforcing effects of cocaine under some schedules of cocaine self-administration and reinstatement, but not in all cases. To date, no studies have used a food-cocaine concurrent choice procedure, which allows for assessment of drug effects on response allocation, not just changes in cocaine self-administration. The goal of the present study was to examine the effects of compounds differing in their efficacy at the cannabinoid receptor (CBR) on cocaine self-administration using a food-drug choice procedure in monkeys. Four adult male rhesus monkeys were trained to self-administer cocaine in the context of an alternative food (1.0-g banana-flavored pellets) reinforcer, such that complete cocaine dose-response curves (0, 0.003-0.1 mg/kg per injection) were determined each session. Monkeys were tested acutely with the CBR full agonist CP 55,940 (0.001-0.01 mg/kg); the CBR partial agonist Δ

Indexed as

AnimalsCannabinoidsChoice BehaviorCocaineCyclohexanolsDopamine Uptake InhibitorsFood PreferencesMacaca mulattaMaleSelf Administration3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolCannabinoidsCocaineCyclohexanolsDopamine Uptake Inhibitors

Identifiers

PMID31941717
PMCPMC7076528
OpenAlexW3000221873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.