Evidence map›Paper›PMID 31941672›Full record

ArticleJournal of lipid research2020

Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores.

Patrick J Heizer, Ye Yang, Yiping Tu, Paul H Kim, Natalie Y Chen, Yan Hu, Yuko Yoshinaga, Pieter J de Jong, Laurent Vergnes, Jazmin E Morales and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Patrick J HeizerDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095.
Ye YangDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095.
Yiping TuDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095.
Paul H KimDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095.
Natalie Y ChenDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095.
Yan HuDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095.
Yuko YoshinagaChildren's Hospital Oakland Research Institute, Oakland, CA 94609.
Pieter J de JongChildren's Hospital Oakland Research Institute, Oakland, CA 94609.
Laurent VergnesHuman Genetics,University of California, Los Angeles, Los Angeles, CA 90095.
Jazmin E MoralesDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095.
Robert L LiDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095.
Nicholas JacksonDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095.
Karen ReueHuman Genetics,University of California, Los Angeles, Los Angeles, CA 90095.
Stephen G YoungDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095; Human Genetics,University of California, Los Angeles, Los Angeles, CA 90095.
Loren G FongDepartments of MedicineUniversity of California, Los Angeles, Los Angeles, CA 90095.
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
The Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2008 to 2018
$23.3M
Vascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4M
Training in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1M
ZMPSTE24, HIV treatment regimens, and atherosclerotic heart diseaseR01HL126551 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2014 to 2017
$1.8M
Development of a New Therapeutic Approach for Prelamin A DiseasesR01AG047192 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2014 to 2018
$1.6M
NCATS NIH HHS UL1 TR001881NHLBI NIH HHS P01 HL090553NHLBI NIH HHS R01 HL126551NHLBI NIH HHS T32 HL069766NIA NIH HHS R01 AG047192NIGMS NIH HHS T32 GM065823
6 · The paper itself

Abstract

Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl-prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl-prelamin A accumulates in the nucleus and exerts toxicity, causing a variety of disease phenotypes. By ∼4 months of age, both male and female

Indexed as

Adipose TissueAllelesAnimalsCell NucleusFemaleLamin Type AMaleMembrane ProteinsMetalloendopeptidasesMiceMice, KnockoutMice, TransgenicLamin Type AMembrane ProteinsMetalloendopeptidasesprelamin AZmpste24 protein, mouseanimal modelsfarnesylationfluorescence microscopylipodystrophiesnuclear laminszinc metallopeptidase STE24

Identifiers

PMID31941672
PMCPMC7053845
OpenAlexW2999707449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.