ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Temporal Invariance in SCA6 Is Related to Smaller Cerebellar Lobule VI and Greater Disease Severity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Linking behavioral variability to daily function in stroke survivors: the mediating role of cognitive and motor mechanisms.Journal of neuroengineering and rehabilitation · 2025Observational
- Cognitive impairment associated with cerebellar volume loss in spinocerebellar ataxia type 3.Journal of neurology · 2024Article
- Quantification of Upper Limb Movements in Patients with Hereditary or Idiopathic Ataxia.Cerebellum (London, England) · 2023Article
- Muscle activity prior to experiencing the rubber hand illusion is associated with alterations in perceived hand location.Psychological research · 2023Article
- Spinocerebellar Ataxia Type 6: A Disorder of Connectivity?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Regulating muscle force and timing are fundamental for accurate motor performance. In spinocerebellar ataxia type 6 (SCA6), there is evidence that individuals have greater force dysmetria but display better temporal accuracy during fast goal directed contractions. Here, we test whether greater temporal accuracy occurs in all individuals with SCA6, and can be explained by lesser temporal variability. Further we examine whether it is linked to disease severity and specific degenerative changes in the cerebellum. Nineteen human participants with SCA6 (13 woman) and 18 healthy controls performed fast goal-directed ankle dorsiflexion contractions aiming at a spatiotemporal target. We quantified the endpoint control of these contractions, gray matter (GM) integrity of the cerebellum, and disease severity using the International Cooperative Ataxia Rating Scale (ICARS). SCA6 individuals exhibited lower temporal endpoint error and variability than the healthy controls (
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Registered trials
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