ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Differential Roles of Mediodorsal Nucleus of the Thalamus and Prefrontal Cortex in Decision-Making and State Representation in a Cognitive Control Task Measuring Deficits in Schizophrenia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed.
- Acute effects of intranasal esketamine application on thalamic structures in healthy individuals.The international journal of neuropsychopharmacology · 2025Trial
- Electrophysiological Brain Connectivity and Subjective States Evoked by Electrical Stimulation of the Human Mid-thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Immense data processing within brain networks in professional gamers.Scientific reports · 2026Article
- From network hub to therapeutic target: the role of mediodorsal thalamic nucleus in epilepsy.Frontiers in neuroscience · 2026Review
- Mediodorsal Thalamic Input to Striatum Contributes to Early Action Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- The neural circuit mechanism for auditory responses in the mediodorsal thalamic nucleus of awake mice.Communications biology · 2025Article
- Mapping Brain-Wide Neural Activity of Murine Attentional Processing in the Five-Choice Serial Reaction Time Task.Neuroscience bulletin · 2025Article
- Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility.Nature communications · 2025Article
- Article
- Anatomical mapping of whole-brain monosynaptic inputs to the orbitofrontal cortex.Frontiers in neural circuits · 2025Article
- Caudal and Thalamic Segregation in White Matter Brain Network Communities in Alzheimer's Disease Population.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2024Article
- Thalamic nuclei segmentation from T1-weighted MRI: Unifying and benchmarking state-of-the-art methods.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- The hidden link: Investigating functional connectivity of rarely explored sub-regions of thalamus and superior temporal gyrus in Schizophrenia.Translational neuroscience · 2024Article
- Neural mechanisms of domain-general inhibitory control.Trends in cognitive sciences · 2023Review
- Variable cardiac responses in rhesus macaque monkeys after discrete mediodorsal thalamus manipulations.Scientific reports · 2023Article
- The impact of the human thalamus on brain-wide information processing.Nature reviews. Neuroscience · 2023Review
- Working memory control dynamics follow principles of spatial computing.Nature communications · 2023Article
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Abstract
The mediodorsal nucleus of the thalamus (MD) is reciprocally connected with the prefrontal cortex (PFC), and although the MD has been implicated in a range of PFC-dependent cognitive functions (Watanabe and Funahashi, 2012; Mitchell and Chakraborty, 2013; Parnaudeau et al., 2018), little is known about how MD neurons in the primate participate specifically in cognitive control, a capability that reflects the ability to use contextual information (such as a rule) to modify responses to environmental stimuli. To learn how the MD-PFC thalamocortical network is engaged to mediate forms of cognitive control that are selectively disrupted in schizophrenia, we trained male monkeys to perform a variant of the AX continuous performance task, which reliably measures cognitive control deficits in patients (Henderson et al., 2012) and used linear multielectrode arrays to record neural activity in the MD and PFC simultaneously. We found that the two structures made clearly different contributions to distributed processing for cognitive control: MD neurons were specialized for decision-making and response selection, whereas prefrontal neurons were specialized to preferentially encode the environmental state on which the decision was based. In addition, we observed that functional coupling between MD and PFC was strongest when the decision as to which of the two responses in the task to execute was being made. These findings delineate unique contributions of MD and PFC to distributed processing for cognitive control and characterized neural dynamics in this network associated with normative cognitive control performance.
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