Evidence map›Paper›PMID 31941578›Full record

ArticleNeurobiology of aging2020

Distance disintegration delineates the brain connectivity failure of Alzheimer's disease.

Víctor Costumero, Federico d'Oleire Uquillas, Ibai Diez, Magi Andorrà, Silvia Basaia, Elisenda Bueichekú, Laura Ortiz-Terán, Vicente Belloch, Joaquin Escudero, César Ávila and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Stepwise Functional Brain Architecture Correlates with Atrophy in Progressive Supranuclear Palsy.Movement disorders : official journal of the Movement Disorder Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Víctor CostumeroGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Catalonia, Spain; Neuropsychology and Functional Neuroimaging Group, Department of basic Psychology, University Jaume I, Castellón, Valencian Community, Spain.
Federico d'Oleire UquillasDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ibai DiezGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Neurotechnology Laboratory, Tecnalia Health Department, Basque Country, Spain.
Magi AndorràGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Center of Neuroimmunology, Department of Neurology, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain.
Silvia BasaiaGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Neuroimaging Research Unit Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Elisenda BueichekúGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Neuropsychology and Functional Neuroimaging Group, Department of basic Psychology, University Jaume I, Castellón, Valencian Community, Spain.
Laura Ortiz-TeránGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Vicente BellochERESA Medical Group, Valencia, Valencian community, Spain.
Joaquin EscuderoDepartment of Neurology, General Hospital of Valencia, Valencia, Valencian Community, Spain.
César ÁvilaNeuropsychology and Functional Neuroimaging Group, Department of basic Psychology, University Jaume I, Castellón, Valencian Community, Spain.
Jorge SepulcreGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. Electronic address: sepulcre@nmr.mgh.harvard.edu.
Harvard University · USUniversitat Jaume I · ESBrigham and Women's Hospital · USHospital General Universitario De Valencia · ES

Funding

Genetic Profiles of the Spatiotemporal Causality of Tau and Amyloid in the Elderly BrainR01AG061445 · NIA · YALE UNIVERSITY · PI SEPULCRE, JORGE · 2019 to 2023
$1.9M
Sensory and Motor Streams in Preclinical and Clinical Stages of Alzheimer's DiseaseR01AG061811 · NIA · YALE UNIVERSITY · PI SEPULCRE, JORGE · 2019 to 2023
$1.7M
Study of Brain Spreading Pathways of Tau and Amyloid-Beta in (pre)clinical ADRF1AG052653 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI LI, QUANZHENG, SEPULCRE, JORGE · 2017 to 2017
$1.4M
In Vivo Visualization of TAU and Amyloid-Beta Networks for Early AD DetectionK23EB019023 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI SEPULCRE, JORGE · 2014 to 2018
$810k
NIA NIH HHS R01 AG061445NIA NIH HHS R01 AG061811NIA NIH HHS RF1 AG052653NIBIB NIH HHS K23 EB019023
6 · The paper itself

Abstract

Alzheimer's disease (AD) is associated with brain network dysfunction. Network-based investigations of brain connectivity have mainly focused on alterations in the strength of connectivity; however, the network breakdown in AD spectrum is a complex scenario in which multiple pathways of connectivity are affected. To integrate connectivity changes that occur under AD-related conditions, here we developed a novel metric that computes the connectivity distance between cortical regions at the voxel level (or nodes). We studied 114 individuals with mild cognitive impairment, 24 with AD, and 27 healthy controls. Results showed that areas of the default mode network, salience network, and frontoparietal network display a remarkable network separation, or greater connectivity distances, from the rest of the brain. Furthermore, this greater connectivity distance was associated with lower global cognition. Overall, the investigation of AD-related changes in paths and distances of connectivity provides a novel framework for characterizing subjects with cognitive impairment; a framework that integrates the overall network topology changes of the brain and avoids biases toward unreferenced connectivity effects.

Indexed as

CognitionExecutive FunctionAgedAlzheimer DiseaseBrainCognitive DysfunctionFemaleHumansMaleNeural PathwaysAlzheimer's diseaseFunctional connectivityGraph-theoryMild Cognitive impairmentOptimal distanceStepwise connectivity

Identifiers

PMID31941578
PMCPMC7085436
OpenAlexW2996515493

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.