ReviewDeutsches Arzteblatt international2019
The Use of Forensic DNA Phenotyping in Predicting Appearance and Biogeographic Ancestry.
Review in Deutsches Arzteblatt international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.
- Advancement in Human Face Prediction Using DNA.Genes · 2023Pooled it
- Development of a Model for Predicting Chronological Age Based on DNA Methylation Data from Buccal Swabs Using Ion Torrent S5 Technology.International journal of molecular sciences · 2026Article
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- Technical reliability of genotyping SNPs for forensic DNA phenotyping using SNaPshot- and MPS-based assays.International journal of legal medicine · 2026Article
- Evaluation of the Prediction Potential of the HIrisPlex-S System in a North German Population.Genes · 2026Article
- Comprehensive analysis of the chloroplast genome in Cannabis sativa L. reveals variations in simple sequence repeats among cultivars.Scientific reports · 2026Article
- Microbial community variations in human salivary samples with different body mass index for forensic research: a pilot study.Frontiers in microbiology · 2026Article
- Moving the Fine Print to the Front Page: Transparent Communication of Facial Genetics Research.Advanced genetics (Hoboken, N.J.) · 2025Article
- Potential of Proteomics in Forensic Phenotyping: A Focus on Biological Sex Estimation.Journal of proteome research · 2025Article
- [Application of HIrisPlex-S System in Forensic DNA Phenotyping].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Implementation of NGS and SNP microarrays in routine forensic practice: opportunities and barriers.BMC genomics · 2025Review
- Forensic DNA phenotyping: a review on SNP panels, genotyping techniques, and prediction models.Forensic sciences research · 2025Review
- The Chromatin Organization Close to SNP rs12913832, Involved in Eye Color Variation, Is Evolutionary Conserved in Vertebrates.International journal of molecular sciences · 2024Article
- RNA Analysis in Forensic Molecular Biology.Deutsches Arzteblatt international · 2024Review
- Assessing Privacy Vulnerabilities in Genetic Data Sets: Scoping Review.JMIR bioinformatics and biotechnology · 2024Article
- Uncovering Forensic Evidence: A Path to Age Estimation through DNA Methylation.International journal of molecular sciences · 2024Review
- Article
- Review
- Prediction of chronological age and its applications in forensic casework: methods, current practices, and future perspectives.Forensic sciences research · 2023Review
- The Revolution of Animal Genomics in Forensic Sciences.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersons whose identifying DNA profile (STR profile) is not yet known to the ingvestigating authorities cannot be identified by standard forensic DNA analysis (STR profiling) as it is now practiced. In view of the current public debate, particularly in Germany, on the legalization of so-called forensic DNA phenotyping, we present its scientific basis, societal aspects, and forensic applications and describe the analytic techniques that are now available.
methodsThis review is based on pertinent publications that were retrieved by a selective search in PubMed and in public media, and on the authors' own research.
resultsForensically validated DNA test systems are available for the categorization of eye, hair, and skin color and the inference of continental biogeographic ancestry. As for statistical measures of test accuracy, the AUC (area under the curve) values lie in the range 0.74-0.99 for eye color, 0.64-0.94 for hair color, and 0.72-0.99 for skin color, depending on the predictive model and color category used.The corre- sponding positive predictive values (PPV) are lower. Empirical social-scientific research on forensic DNA phenotyping has shown that preserving privacy and protecting against discrimination are major ethical and regulatory considerations.
conclusionAll three methods of forensic DNA phenotyping-the predition of exter- nally visible characteristics, biogeographic ancestry, and the estimation of age from crime scene DNA-require a proper regulatory framework and should be used in conjunction with each other. Before forensic DNA phenotyping can be implemented in forensic practice, steps must be taken to minimize the risks of violation of privacy scrimination and to ensure that these methods are used transpar- ently and proportionately.
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