ArticleJournal of cardiothoracic surgery2020
Preoperative uric acid predicts in-hospital death in patients with acute type a aortic dissection.
Article in Journal of cardiothoracic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Prognostic factors and prediction models for acute aortic dissection: a systematic review.BMJ open · 2021Pooled it
- Prognostic Value of a Composite Inflammation-Renal Function Score in Type A Aortic Dissection.Journal of cardiovascular development and disease · 2026Article
- Interpretable prognostic modeling for long-term survival of Type A aortic dissection patients using support vector machine algorithm.European journal of medical research · 2025Article
- Prognostic prediction of long-term survival in patients with type A aortic dissection undergoing surgical repair: development of a novel prognostic index.BMC cardiovascular disorders · 2025Article
- Gout and Hyperuricemia: A Narrative Review of Their Comorbidities and Clinical Implications.Journal of clinical medicine · 2024Review
- Effect of serum uric acid on the risk of aortic aneurysm and dissection: A mendelian randomization analysis.Biochemistry and biophysics reports · 2024Article
- Impact of D-dimer on in-hospital mortality following aortic dissection: A systematic review and meta-analysis.World journal of cardiology · 2024Article
- Hyperuricaemia Does Not Interfere with Aortopathy in a Murine Model of Marfan Syndrome.International journal of molecular sciences · 2023Article
- Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications.International journal of biological sciences · 2023Review
- A retrospective observational study of serum uric acid and in-hospital mortality in acute type A aortic dissection.Scientific reports · 2022Observational
- Serum sodium on admission affects postoperative in-hospital mortality in acute aortic dissection patients.PloS one · 2021Observational
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe present study aimed to evaluate the value of admission serum uric acid (UA) level in predicting in-hospital risk of death in patients with acute type A aortic dissection (AAAD).
methodsFrom January 2016 to June 2019, 186 consecutive patients with AAAD who underwent thoracic aortic surgery were retrospectively studied. Serum UA levels were measured on admission. Forward conditional logistic regression was performed to identify independent risk factors for in-hospital death. Receiver operating characteristic (ROC) analysis was performed to assess the most clinical useful level of serum UA for predicting postoperative in-hospital mortality.
resultsIncreased level of serum UA was found in non-survivors compared with those survived (446 ± 123 vs 371 ± 111 umol/L, p < 0.001). Age (OR = 1.063, 95% CI 1.016-1.112, p = 0.009), UA (OR = 1.006, 95% CI 1.002-1.010, p = 0.002), D-dimer (OR = 1.025, 95% CI 1.005-1.013, p = 0.012), operation time (OR = 1.009, 95% CI 1.005-1.013, p < 0.001) and extent of aortic replacement (OR = 0.412, 95% CI 0.220-0.768, p = 0.005) were identified as independent risk factors of in-hospital mortality in AAAD patients. The best cut-off value of admission serum UA in predicting in-hospital mortality was determined to be 415 umol/L. Subgroup analysis showed that in the subgroup of total arch replacement, UA was significantly associated with in-hospital death (OR = 1.010, 95% CI 1.005-1.015, p < 0.001), while in patients underwent ascending aorta replacement or hemiarch replacement, the relationship was no longer significant (OR = 1.001, 95% CI 0.996-1.006, p = 0.611).
conclusionsElevated serum UA level on admission is an independent predictor of in-hospital mortality in patients with AAAD.
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