ArticleCardiovascular ultrasound2020
Regional myocardial strain analysis via 2D speckle tracking echocardiography: validation with sonomicrometry and correlation with regional blood flow in the presence of graded coronary stenoses and dobutamine stress.
Article in Cardiovascular ultrasound, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Speckle-tracking and conventional echocardiography in MIS-C: tracking cardiac involvement and recovery.BMC pediatrics · 2025Article
- Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging.IEEE transactions on bio-medical engineering · 2024Article
- Multi-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography.IEEE transactions on medical imaging · 2024Article
- Speckle tracking echocardiography for evaluation of myocardial functions before and after mitral valvuloplasty in dogs.Frontiers in veterinary science · 2024Article
- Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress.American journal of physiology. Heart and circulatory physiology · 2023Article
- Preliminary Feasibility of Stress Myocardial Elastography for the Detection of Coronary Artery Disease.Ultrasound in medicine & biology · 2023Article
- Simultaneous Segmentation and Motion Estimation of Left Ventricular Myocardium in 3D Echocardiography Using Multi-task Learning.Statistical atlases and computational models of the heart. STACOM (Workshop) · 2022Article
- Learning-Based Regularization for Cardiac Strain Analysis via Domain Adaptation.IEEE transactions on medical imaging · 2021Article
- Role of Two-Dimensional Speckle-Tracking Echocardiography in Early Detection of Left Ventricular Dysfunction in Dogs.Animals : an open access journal from MDPI · 2021Review
- SHAPE-REGULARIZED UNSUPERVISED LEFT VENTRICULAR MOTION NETWORK WITH SEGMENTATION CAPABILITY IN 3D+TIME ECHOCARDIOGRAPHY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2021Article
- A Semi-supervised Joint Network for Simultaneous Left Ventricular Motion Tracking and Segmentation in 4D Echocardiography.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2020Article
- Computed Tomographic Angiography Assessment of Epicardial Coronary Vasoreactivity for Early Detection of Doxorubicin-Induced Cardiotoxicity.JACC. CardioOncology · 2020Article
- Multi-frame Attention Network for Left Ventricle Segmentation in 3D Echocardiography.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionArticle
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundQuantitative regional strain analysis by speckle tracking echocardiography (STE) may be particularly useful in the assessment of myocardial ischemia and viability, although reliable measurement of regional strain remains challenging, especially in the circumferential and radial directions. We present an acute canine model that integrates a complex sonomicrometer array with microsphere blood flow measurements to evaluate regional myocardial strain and flow in the setting of graded coronary stenoses and dobutamine stress. We apply this unique model to rigorously evaluate a commercial 2D STE software package and explore fundamental regional myocardial flow-function relationships.
methodsSonomicrometers (16 crystals) were implanted in epicardial and endocardial pairs across the anterior myocardium of anesthetized open chest dogs (n = 7) to form three adjacent cubes representing the ischemic, border, and remote regions, as defined by their relative locations to a hydraulic occluder on the mid-left anterior descending coronary artery (LAD). Additional cardiac (n = 3) and extra-cardiac (n = 3) reference crystals were placed to define the cardiac axes and aid image registration. 2D short axis echocardiograms, sonometric data, and microsphere blood flow data were acquired at baseline and in the presence of mild and moderate LAD stenoses, both before and during low-dose dobutamine stress (5 μg/kg/min). Regional end-systolic 2D STE radial and circumferential strains were calculated with commercial software (EchoInsight) and compared to those determined by sonomicrometry and to microsphere blood flow measurements. Post-systolic indices (PSIs) were also calculated for radial and circumferential strains.
resultsLow-dose dobutamine augmented both strain and flow in the presence of mild and moderate stenoses. Regional 2D STE strains correlated moderately with strains assessed by sonomicrometry (R
conclusions2D STE identifies changes in regional end-systolic circumferential and radial strain produced by mild and moderate coronary stenoses and low-dose dobutamine stress. Regional 2D STE end-systolic strain measurements correlate modestly with regional sonomicrometer strain and microsphere flow measurements.
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