ArticleBMC cancer2020
Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report.
Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Cancer therapy and cachexia.The Journal of clinical investigation · 2025Review
- Pancreatic adenosquamous carcinoma: A population level analysis of epidemiological trends and prognosis.Cancer medicine · 2023Article
- Pancreatic Adenosquamous Carcinoma: A Rare Pathological Subtype of Pancreatic Cancer.Journal of clinical medicine · 2022Review
- Chemotherapy is associated with improved survival in a national cohort of stage IV pancreatic adenosquamous carcinoma.Journal of gastrointestinal oncology · 2022Article
- Adenosquamous carcinoma of the pancreas: two case reports and review of the literature.Journal of medical case reports · 2022Review
- Survival Analysis and Prediction Model of ASCP Based on SEER Database.Frontiers in oncology · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPancreatic adenosquamous carcinoma has a poor prognosis, with limited prospective trial data to guide optimal treatment. The potential impact of drug metabolism on the treatment response of patients with pancreatic adenosquamous carcinoma is largely unknown. CASE PRESENTATION: We describe the case of a 51 year old woman with pancreatic adenosquamous carcinoma who, following surgical resection, experienced early disease relapse during adjuvant gemcitabine therapy. Paradoxically, this was followed by an exceptional response to capecitabine therapy lasting 34.6 months. Strong expression of cytidine deaminase was detected within the tumour.
conclusionsThis case study demonstrates that early relapse during adjuvant chemotherapy for pancreatic adenosquamous carcinoma may be compatible with a subsequent exceptional response to second line chemotherapy, an important observation given the poor overall prognosis of patients with adenosquamous carcinoma. Cytidine deaminase is predicted to inactivate gemcitabine and, conversely, catalyze capecitabine activation. We discuss strong intra-tumoural expression of cytidine deaminase as a potential mechanism to explain this patient's disparate responses to gemcitabine and capecitabine therapy, and highlight the benefit that may be gained from considering similar determinants of response to chemotherapy in clinical practice.
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