Evidence map›Paper›PMID 31941438›Full record

ArticleJournal of neurodevelopmental disorders2020

Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model.

J L Lukkes, H P Drozd, S D Fitz, A I Molosh, D W Clapp, A Shekhar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Blockade of Serotonin 5-HTInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J L LukkesDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. jodiburk@iu.edu.ORCID 0000-0001-6450-6834
H P DrozdStark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, Indianapolis, IN, 46202, USA.
S D FitzDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
A I MoloshDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
D W ClappStark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, Indianapolis, IN, 46202, USA.
A ShekharDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Funding

NEUROBIOLOGY OF PANIC AND ANXIETY DISORDERSR01MH052619 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SHEKHAR, ANANTHA · 1996 to 2016
$5.0M
Neurofibromatosis Type 1 Gene Regulates MyelopoiesisR01CA074177 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CLAPP, DAVID W · 2002 to 2012
$3.6M
Serotonin and CRF Pathways in Anxiety &HPA RegulationR01MH065702 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI LOWRY, CHRISTOPHER A, SHEKHAR, ANANTHA · 2003 to 2013
$2.8M
NCI NIH HHS R01 CA74177NIMH NIH HHS R01 MH052619NIMH NIH HHS R01MH065702
6 · The paper itself

Abstract

backgroundNeurofibromatosis type 1 (NF1) is an autosomal dominant disorder with a mutation in one copy of the neurofibromin gene (NF1

methodsWe compared wild-type (WT) and Nf1

resultsNf1

conclusionsOverall, our study confirms that Nf1

Indexed as

Adrenergic alpha-2 Receptor AgonistsAnimalsAttention Deficit Disorder with HyperactivityDisease Models, AnimalGuanfacineImpulsive BehaviorInhibition, PsychologicalMaleMiceNeurofibromatosis 1PhenotypeRewardAdrenergic alpha-2 Receptor AgonistsGuanfacineADHDAlpha 2A-adrenergic receptor agonistBehavioral inhibitionCliff avoidance reaction testDelay discountingGuanfacineHyperactivityImpulsivityMouseNeurofibromatosis type 1

Identifiers

PMID31941438
PMCPMC6961243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.