ArticleThe journal of physical chemistry. B2020
Femtosecond Fluorescence Spectra of NADH in Solution: Ultrafast Solvation Dynamics.
Article in The journal of physical chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Assessing cellular metabolic dynamics with two-photon NAD(P)H fluorescence polarization microscopy.Science advances · 2026Article
- Sub-100-fs energy transfer in coenzyme NADH is a coherent process assisted by a charge-transfer state.Nature communications · 2024Article
- Ultrafast fluorescence dynamics of NADH in aprotic solvents: Quasi-static self-quenching unmasked.Journal of photochemistry and photobiology. A, Chemistry · 2023Article
- Nature of Linear Spectral Properties and Fast Electronic Relaxations in Green Fluorescent Pyrrolo[3,4-c]Pyridine Derivative.International journal of molecular sciences · 2021Article
- Ultrafast Fluorescence Spectroscopy via Upconversion and Its Applications in Biophysics.Molecules (Basel, Switzerland) · 2021Review
- Dehydrogenase Binding Sites Abolish the "Dark" Fraction of NADH: Implication for Metabolic Sensing via FLIM.The journal of physical chemistry. B · 2020Article
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Authors and funding
10 authors.
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Abstract
The ultrafast solvation dynamics of reduced nicotinamide adenine dinucleotide (NADH) free in solution has been investigated, using both a femtosecond upconversion spectrophotofluorometer and a picosecond time-correlated single-photon counting (TCSPC) apparatus. The familiar time constant of solvent relaxation originating in "bulk water" was found to be ∼1.4 ps, revealing ultrafast solvent reorientation upon excitation. We also found a slower spectral relaxation process with an apparent time of 27 ps, suggesting there could either be dissociable "biological water" hydration sites on the surface of NADH or internal dielectric rearrangements of the flexible solvated molecule on that timescale. In contrast, the femtosecond fluorescence anisotropy measurement revealed that rotational diffusion happened on two different timescales (3.6 ps (local) and 141 ps (tumbling)); thus, any dielectric rearrangement scenario for the 27 ps relaxation must occur without significant chromophore oscillator rotation. The coexistence of quasi-static self quenching (QSSQ) with the slower relaxation is also discussed.
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