Evidence map›Paper›PMID 31941125›Full record

ArticleMolecules (Basel, Switzerland)2020

In Silico and In Vitro Experimental Studies of New Dibenz[

Ilinca Margareta Vlad, Diana Camelia Nuta, Cornel Chirita, Miron Teodor Caproiu, Constantin Draghici, Florea Dumitrascu, Coralia Bleotu, Speranța Avram, Ana Maria Udrea, Alexandru Vasile Missir and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ilinca Margareta VladDepartment of Pharmaceutical Chemistry, University of Medicine and Pharmacy "Carol Davila", Traian Vuia 6, sect. 2, 020956 Bucharest, Romania.
Diana Camelia NutaDepartment of Pharmaceutical Chemistry, University of Medicine and Pharmacy "Carol Davila", Traian Vuia 6, sect. 2, 020956 Bucharest, Romania.ORCID 0000-0002-7685-3291
Cornel ChiritaDepartment of Pharmacology and Clinical Pharmacy, University of Medicine and Pharmacy "Carol Davila", Traian Vuia 6, sect. 2, 020956 Bucharest, Romania.
Miron Teodor CaproiuThe Organic Chemistry Center of Romanian Academy "Costin D. Nenitescu", Splaiul Independenței 202B, 77208 Bucharest, Romania.
Constantin DraghiciThe Organic Chemistry Center of Romanian Academy "Costin D. Nenitescu", Splaiul Independenței 202B, 77208 Bucharest, Romania.
Florea DumitrascuThe Organic Chemistry Center of Romanian Academy "Costin D. Nenitescu", Splaiul Independenței 202B, 77208 Bucharest, Romania.
Coralia BleotuȘtefan S Nicolau Institute of Virology, Romanian Academy, 285 Mihai Bravu Avenue, 030304 Bucharest, Romania.ORCID 0000-0002-9031-338X
Speranța AvramDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 1-3 Ale. Portocalelor, 060101 Bucharest, Romania.
Ana Maria UdreaDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 1-3 Ale. Portocalelor, 060101 Bucharest, Romania.ORCID 0000-0002-7659-7435
Alexandru Vasile MissirDepartment of Pharmaceutical Chemistry, University of Medicine and Pharmacy "Carol Davila", Traian Vuia 6, sect. 2, 020956 Bucharest, Romania.
Luminita Gabriela MarutescuResearch Institute of the University of Bucharest (ICUB) and Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 1-3 Ale. Portocalelor, 060101 Bucharest, Romania.
Carmen LimbanDepartment of Pharmaceutical Chemistry, University of Medicine and Pharmacy "Carol Davila", Traian Vuia 6, sect. 2, 020956 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · ROUniversity of Bucharest · RORomanian Academy · RO

Funding

UEFISCDI PDI-PFE-CDI ID 335-2018 2020UEFISCDI PNCDI III - 52PCCDI/2018
6 · The paper itself

Abstract

In a drug-repurposing-driven approach for speeding up the development of novel antimicrobial agents, this paper presents for the first time in the scientific literature the synthesis, physico-chemical characterization, in silico analysis, antimicrobial activity against bacterial and fungal strains in planktonic and biofilm growth state, as well as the in vitro cytotoxicity of some new 6,11-dihydrodibenz[

Indexed as

Anti-Infective AgentsComputer SimulationOximesBacteriaBacterial Physiological PhenomenaBiofilmsCandida albicansCell LineHumansAnti-Infective AgentsOximesantibacterialantibiofilmantifungaldibenz[b,e]oxepinsin silicoin vitro cytotoxicityoxime carbamates

Identifiers

PMID31941125
PMCPMC7024208
OpenAlexW3000720869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.