Evidence map›Paper›PMID 31941070›Full record

ReviewDiagnostics (Basel, Switzerland)2020

Biomarkers for Bladder Cancer Diagnosis and Surveillance: A Comprehensive Review.

Rui Batista, Nuno Vinagre, Sara Meireles, João Vinagre, Hugo Prazeres, Ricardo Leão, Valdemar Máximo, Paula Soares

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. The bladder cancer mEMBO reports · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Bladder cancer biomarkers.Exploration of targeted anti-tumor therapy · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Bladder Cancer and Artificial Intelligence: Emerging Applications.The Urologic clinics of North America · 2024
    Review
  20. Relevance ofCancers · 2024
    Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rui Batistai3S-Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Portugal.
Nuno Vinagrei3S-Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Portugal.
Sara Meirelesi3S-Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Portugal.
João Vinagrei3S-Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Portugal.ORCID 0000-0002-0871-1427
Hugo Prazeresi3S-Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Portugal.
Ricardo LeãoUrology department, Hospital de Braga, 4710-243 Braga, Portugal.
Valdemar Máximoi3S-Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Portugal.ORCID 0000-0002-8631-8356
Paula Soaresi3S-Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Portugal.ORCID 0000-0001-9607-6998
Universidade do Porto · PTHospital Braga · PTInstituto Português de Oncologia de Coimbra Francisco Gentil · PT

Funding

European Regional Development Fund PTDC/MED-ONC/31438/2017Fundação para a Ciência e a Tecnologia POCI-01-0145-FEDER-016390:CANCEL STEMFundação para a Ciência e a Tecnologia SFRH/ BD/111321/2015Norte 2020 - Programa Operacional Regional do Norte NORTE-01-0145-FEDER-000029:Operational Programme for Competitiveness and Internationalisation- COMPETE 2020 POCI-01-0145-FEDER-016390:CANCEL STEM
6 · The paper itself

Abstract

Bladder cancer (BC) ranks as the sixth most prevalent cancer in the world, with a steady rise in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is a complex disease with several molecular and pathological pathways, thus reflecting different behaviors depending on the clinical staging of the tumor and molecular type. Diagnosis and monitoring of BC is mainly performed by invasive tests, namely periodic cystoscopies; this procedure, although a reliable method, is highly uncomfortable for the patient and it is not exempt of comorbidities. Currently, there is no formal indication for the use of molecular biomarkers in clinical practice, even though there are several tests available. There is an imperative need for a clinical non-invasive testing for early detection, disease monitoring, and treatment response in BC. In this review, we aim to assess and compare different tests based on molecular biomarkers and evaluate their potential role as new molecules for bladder cancer diagnosis, follow-up, and treatment response monitoring.

Indexed as

biomarkerbladder cancerblood testnon-invasive testTERT promoter mutationurinary test

Identifiers

PMID31941070
PMCPMC7169395
OpenAlexW3000043013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.