Evidence map›Paper›PMID 31941061›Full record

ArticleCancers2020

Molecular Classification of Gastric Cancer among Alaska Native People.

Holly A Martinson, Dominic Mallari, Christine Richter, Tsung-Teh Wu, James Tiesinga, Steven R Alberts, Matthew J Olnes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Implications of lncRNAs inFrontiers in cellular and infection microbiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Holly A MartinsonWWAMI School of Medical Education, University of Alaska Anchorage, 3211 Providence Drive, Anchorage, AK 99508, USA.
Dominic MallariDepartment of Chemistry, University of Alaska Anchorage, 3211 Providence Drive, Anchorage, AK 99508, USA.
Christine RichterDepartment of Biological Sciences, University of Alaska Anchorage, 3211 Providence Drive, Anchorage, AK 99508, USA.
Tsung-Teh WuDepartment of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, 200 First Street SW, Rochester, MN 55905, USA.
James TiesingaDepartment of Pathology and Clinical Laboratory, Alaska Native Medical Center, 4315 Diplomacy Drive, Anchorage, AK 99508, USA.
Steven R AlbertsMedical Oncology, Mayo Clinic Cancer Center, 200 First Street SW, Rochester, MN 55905, USA.
Matthew J OlnesOncology and Hematology, Alaska Native Medical Center, 4315 Diplomacy Drive, Anchorage, AK 99508, USA.
Alaska Native Medical Center · USMayo Clinic · USUniversity of Alaska Anchorage · USProvidence College · US

Funding

The Administrative CoreP20GM103395 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI BRIAN M BARNES · 2012 to 2026
$66.1M
EXITO: Enhancing Cross-disciplinary Infrastructure and Training at OregonUL1GM118964 · NIGMS · PORTLAND STATE UNIVERSITY · PI KELLER, THOMAS E · 2015 to 2023
$18.0M
EXITO: Enhancing Cross-disciplinary Infrastructure and Training at OregonRL5GM118963 · NIGMS · PORTLAND STATE UNIVERSITY · PI KELLER, THOMAS E · 2015 to 2023
$11.9M
American Association for Cancer Research 16-40-41-MARTNIGMS NIH HHS P20 GM103395NIGMS NIH HHS RL5 GM118963NIGMS NIH HHS UL1 GM118964NIH HHS P20GM103395
6 · The paper itself

Abstract

Gastric cancer is an aggressive and heterogeneous malignancy that often varies in presentation and disease among racial and ethnic groups. The Alaska Native (AN) people have the highest incidence and mortality rates of gastric cancer in North America. This study examines molecular markers in solid tumor samples from eighty-five AN gastric adenocarcinoma patients using next-generation sequencing, immunohistochemistry, and in situ hybridization analysis. AN patients have a low mutation burden with fewer somatic gene mutations in their tumors compared to other populations, with the most common mutation being

Indexed as

Alaska Native peopleCOX-2diffuseEpstein-Barr virusHelicobacter pyloriMismatch repair deficiencyMUC1PD-L1signet ringTP53

Identifiers

PMID31941061
PMCPMC7016562
OpenAlexW2998793499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.