Evidence map›Paper›PMID 31941024›Full record

ReviewInternational journal of environmental research and public health2020

Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage.

Rama Natarajan, Dana Aljaber, Dawn Au, Christine Thai, Angelica Sanchez, Alan Nunez, Cristal Resto, Tanya Chavez, Marta M Jankowska, Tarik Benmarhnia and 10 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Obesity increases DNA damage in the breast epithelium.Breast cancer research : BCR · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Breast cancer: Epidemiology, risk factors and screening.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2023
    Article
  10. Review
  11. Safety in Cosmetics and Cosmetovigilance, Current Regulations in Türkiye.Turkish journal of pharmaceutical sciences · 2022
    Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Gland surgery · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Rama NatarajanCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.ORCID 0000-0003-4494-1788
Dana AljaberCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.ORCID 0000-0003-1733-7999
Dawn AuCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Christine ThaiCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Angelica SanchezCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Alan NunezCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Cristal RestoCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Tanya ChavezCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Marta M JankowskaQualcomm Institute/Calit2, University of California at San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-8688-1181
Tarik BenmarhniaFamily Medicine and Public Health San Diego, University of California at San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-4018-3089
Jiue-An YangQualcomm Institute/Calit2, University of California at San Diego, San Diego, CA 92093, USA.ORCID 0000-0003-4246-0470
Veronica JonesCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Jerneja TomsicCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Jeannine S McCuneCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.ORCID 0000-0002-0795-497X
Christopher SistrunkCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Stacey DoanCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Mayra SerranoCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Robert D CardiffCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Eric C DietzeCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Victoria L SeewaldtCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
City of Hope · USQualcomm (United States) · USClaremont McKenna College · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Inflammatory Gene Transcription In Diabetic ConditionsR01DK065073 · NIDDK · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI NATARAJAN, RAMA · 2003 to 2021
$7.9M
Diversity Supplement to Combined Breast MRI/Biomarker Strategies to Identify Aggressive BiologyU01CA189283 · NCI · DUKE UNIVERSITY · PI CLINTON, STEVEN K, MIRANDA-CARBONI, GUSTAVO ADOLFO · 2015 to 2020
$4.0M
Epigenetic damage in women living in LA food-desert zip codesR01CA220693 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ANN, DAVID K., HYSLOP, TERRY · 2017 to 2021
$3.7M
Tension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9M
Mechanisms of breast cancer associated with obesityR01CA170851 · NCI · TUFTS UNIVERSITY BOSTON · PI KUPERWASSER, CHARLOTTE, SEEWALDT, VICTORIA L. · 2012 to 2015
$2.6M
NCI NIH HHS R01 CA170851NCI NIH HHS R01 CA192914NCI NIH HHS R01 CA220693NCI NIH HHS U01 CA189283
6 · The paper itself

Abstract

During puberty, a woman's breasts are vulnerable to environmental damage ("window of vulnerability"). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized to promote molecular damage that increases breast cancer risk. However, prospective human studies are difficult to perform and effective interventions to prevent these early exposures are lacking. It is difficult to prevent environmental exposures during puberty. Specifically, young women are repeatedly exposed to media messaging that promotes unhealthy foods. Young women living in disadvantaged neighborhoods experience additional challenges including a lack of access to healthy food and exposure to contaminated air, water, and soil. The purpose of this review is to gather information on potential exposures during puberty. In future directions, this information will be used to help elementary/middle-school girls to identify and quantitate environmental exposures and develop cost-effective strategies to reduce exposures.

Indexed as

Environmental ExposureBreast NeoplasmsDisease SusceptibilityEpigenesis, GeneticFemaleHumansNutritional StatusObesityPubertyResidence CharacteristicsRisk FactorsStress, PhysiologicalStress, Psychologicalbreast cancer riskempowermentenvironment

Identifiers

PMID31941024
PMCPMC7013753
OpenAlexW2999202196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.