Evidence map›Paper›PMID 31941015›Full record

ReviewInternational journal of molecular sciences2020

Sarcopenic Obesity, Insulin Resistance, and Their Implications in Cardiovascular and Metabolic Consequences.

So-Hyeon Hong, Kyung Mook Choi

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 236 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed, 11 pooled it
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05826210 completednot on this map

Effect of Sarcopenic Obesity on Weight Loss Outcomes and Quality of Life After Laparoscopic Sleeve Gastrectomy

TypeobservationalSponsorFujian Medical UniversityRan2015 to 2022Enrolled245ConditionsSarcopenic Obesity, Body CompositionArmsLaparoscopic sleeve gastrectomy
NCT07602959 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Investigation of the Effects of Whole Body Vibration Application on Muscle Functional Level, Physical Fitness and Respiratory Parameters After Bariatric Surgery

TypeinterventionalSponsorKirsehir Ahi Evran UniversitesiRan2026 to 2026Enrolled60ConditionsObesity & Overweight, Morbid Obesity, Morbid Obesity Requiring Bariatric SurgeryArmsResistance Training, Whole Body Vibration, Control Group
3 · Its place in the literature

Who cites it

236 citing papers in PubMed, 11 syntheses or guidelines pooled it, 335 citations in OpenAlex.

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  8. Guideline
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  11. Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  12. Trial
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  15. Article
  16. Observational
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  19. Visceral Adiposity Is Independently Associated with Hypertension in Thai Adults: A Case-Control Study.International journal of environmental research and public health · 2026
    Article
  20. Review

176 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

So-Hyeon HongDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul 08308, Korea.
Kyung Mook ChoiDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul 08308, Korea.ORCID 0000-0001-6175-0225
Korea University · KR

Funding

Korea Christian University Q1625561
6 · The paper itself

Abstract

The prevalence of sarcopenic obesity is increasing worldwide, particularly amongst aging populations. Insulin resistance is the core mechanism of sarcopenic obesity and is also associated with variable cardiometabolic diseases such as cardiovascular disease, type 2 diabetes mellitus, and non-alcoholic fatty liver disease. Fat accumulation in muscle tissue promotes a proinflammatory cascade and oxidative stress, leading to mitochondrial dysfunction, impaired insulin signaling, and muscle atrophy. To compound the problem, decreased muscle mass aggravates insulin resistance. In addition, the crosstalk between myokines and adipokines leads to negative feedback, which in turn aggravates sarcopenic obesity and insulin resistance. In this review, we focus on the molecular mechanisms linking sarcopenic obesity and insulin resistance with various biological pathways. We also discuss the impact and mechanism of sarcopenic obesity and insulin resistance on cardiometabolic disease.

Indexed as

Insulin ResistanceAnimalsCardiovascular DiseasesDiabetes Mellitus, Type 2HumansMitochondria, LiverMitochondria, MuscleNon-alcoholic Fatty Liver DiseaseObesitySarcopeniacardiometabolic diseaseinsulin resistancesarcopenic obesity

Identifiers

PMID31941015
PMCPMC7013734
OpenAlexW2999215393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.