ArticleInternational journal of molecular sciences2020
Novel Segmented Concentration Addition Method to Predict Mixture Hormesis of Chlortetracycline Hydrochloride and Oxytetracycline Hydrochloride to
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
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- Functionalized Magnetite Nanoparticles: Characterization, Bioeffects, and Role of Reactive Oxygen Species in Unicellular and Enzymatic Systems.International journal of molecular sciences · 2023Article
- Marine Bacteria under Low-Intensity Radioactive Exposure: Model Experiments.International journal of molecular sciences · 2022Review
- Endohedral Gd-Containing Fullerenol: Toxicity, Antioxidant Activity, and Regulation of Reactive Oxygen Species in Cellular and Enzymatic Systems.International journal of molecular sciences · 2022Article
- Adaptation of a Bacterial Bioluminescent Assay to Monitor Bioeffects of Gold Nanoparticles.Bioengineering (Basel, Switzerland) · 2022Article
- Development of Cellular and Enzymatic Bioluminescent Assay Systems to Study Low-Dose Effects of Thorium.Bioengineering (Basel, Switzerland) · 2021Article
- Enzymatic Responses to Low-Intensity Radiation of Tritium.International journal of molecular sciences · 2020Article
- Humic Substances Mitigate the Impact of Tritium on Luminous Marine Bacteria. Involvement of Reactive Oxygen Species.International journal of molecular sciences · 2020Article
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9 authors.
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Abstract
Hormesis is a concentration-response phenomenon characterized by low-concentration stimulation and high-concentration inhibition, which typically has a nonmonotonic J-shaped concentration-response curve (J-CRC). The concentration addition (CA) model is the gold standard for studying mixture toxicity. However, the CA model had the predictive blind zone (PBZ) for mixture J-CRC. To solve the PBZ problem, we proposed a segmented concentration addition (SCA) method to predict mixture J-CRC, which was achieved through fitting the left and right segments of component J-CRC and performing CA prediction subsequently. We selected two model compounds including chlortetracycline hydrochloride (CTCC) and oxytetracycline hydrochloride (OTCC), both of which presented J-CRC to
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