Evidence map›Paper›PMID 31940843›Full record

ArticleInternational journal of molecular sciences2020

Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity.

Evelyn Gaffal, Andrea M Kemter, Stefanie Scheu, Rafael Leite Dantas, Jens Vogt, Bernhard Baune, Thomas Tüting, Andreas Zimmer, Judith Alferink

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. The Impact of the CBMolecules (Basel, Switzerland) · 2024
    Review
  5. AMolecules (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. The Immune Endocannabinoid System of the Tumor Microenvironment.International journal of molecular sciences · 2020
    Review
  10. Role of Dendritic Cells in Inflammation.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Evelyn GaffalDepartment of Dermatology, University Hospital Magdeburg, 39104 Magdeburg, Germany.ORCID 0000-0002-4639-9841
Andrea M KemterInstitute of Molecular Psychiatry, University of Bonn, 53127 Bonn, Germany.
Stefanie ScheuInstitute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-9707-8191
Rafael Leite DantasDepartment of Psychiatry, University of Münster, 48149 Münster, Germany.ORCID 0000-0001-7358-990X
Jens VogtDepartment of Psychiatry, University of Münster, 48149 Münster, Germany.
Bernhard BauneDepartment of Psychiatry, University of Münster, 48149 Münster, Germany.
Thomas TütingDepartment of Dermatology, University Hospital Magdeburg, 39104 Magdeburg, Germany.
Andreas ZimmerInstitute of Molecular Psychiatry, University of Bonn, 53127 Bonn, Germany.
Judith AlferinkDepartment of Psychiatry, University of Münster, 48149 Münster, Germany.
University of Münster · DEUniversity Hospital Magdeburg · DEUniversity of Bonn · DEDüsseldorf University Hospital · DEThe University of Melbourne · AU

Funding

Deutsche Forschungsgemeinschaft DFG EXC 1003; Grant FF-2014-01 Cells in Motion-Cluster of Excellence to JADeutsche Forschungsgemeinschaft DFG EXC 1023 Cluster of Excellence ImmunoSensation (EXC 1023) to AZDeutsche Forschungsgemeinschaft DFG-FOR926 to JA, EG and AZDeutsche Forschungsgemeinschaft SCHE692/3-1, SCHE692/4-1 to SSIMF (University Münster) I-ST111423 and I-DL121204 to JAIZKF Münster Alf3/018/16 to JAStrategic Research Fund of the Heinrich Heine University Düsseldorf Strategic Research Fund of the Heinrich Heine University Düsseldorf to SS
6 · The paper itself

Abstract

Contact hypersensitivity (CHS) is an established animal model for allergic contact dermatitis. Dendritic cells (DCs) play an important role in the sensitization phase of CHS by initiating T cell responses to topically applied haptens. The cannabinoid receptors 1 (CB1) and 2 (CB2) modulate DC functions and inflammatory skin responses, but their influence on the capacity of haptenized DCs to induce CHS is still unknown. We found lower CHS responses to 2,4-dinitro-1-fluorobenzene (DNFB) in wild type (WT) mice after adoptive transfer of haptenized

Indexed as

AnimalsCell DifferentiationCells, CulturedChemotaxisDendritic CellsDermatitis, Allergic ContactDinitrofluorobenzeneHistocompatibility AntigensMiceMice, Inbred C57BLReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CCR4Receptors, CCR7Ccr4 protein, mouseCcr7 protein, mouseCNR1 protein, mouseCnr2 protein, mouseDinitrofluorobenzeneHistocompatibility AntigensReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CCR4Receptors, CCR7allergic contact dermatitiscannabinoid receptorsCB1CB2CCL19CXCL12dendritic cellshapten 2,4-dinitro-1-fluorobenzeneMHCmigrationskin inflammation

Identifiers

PMID31940843
PMCPMC7013892
OpenAlexW3000629617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.