Evidence map›Paper›PMID 31940763›Full record

ArticleInternational journal of environmental research and public health2020

Autism Spectrum Disorders: Prenatal Genetic Testing and Abortion Decision-Making among Taiwanese Mothers of Affected Children.

Wei-Ju Chen, Shixi Zhao, Tse-Yang Huang, Oi-Man Kwok, Lei-Shih Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Systematic Review: The Psychosocial Impacts of Autism-Related Genetic Testing.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Wei-Ju ChenPsychology Department, The University of Texas Permian Basin, Odessa, TX 79762, USA.
Shixi ZhaoDepartment of Health, Exercise, and Sports Sciences, University of New Mexico, Albuquerque, NM 87131, USA.
Tse-Yang HuangDepartment of Special Education, National Tsing Hua University, Hsinchu 30013, Taiwan.
Oi-Man KwokDepartment of Educational Psychology, Texas A&M University, College Station, TX 77843, USA.
Lei-Shih ChenDepartment of Health and Kinesiology, Texas A&M University, College Station, TX 77843, USA;.ORCID 0000-0001-5320-6350
Texas A&M University · USNational Tsing Hua University · TWThe University of Texas of the Permian Basin · USUniversity of New Mexico · US

Funding

Transdisciplinary Research, Equity and Engagement Center for Advancing Behavioral HealthU54MD004811 · NIMHD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CACARI STONE, LISA MARIE · 2017 to 2022
$8.7M
NIMHD NIH HHS U54 MD004811
6 · The paper itself

Abstract

With the rapid growing rate of autism spectrum disorders (ASDs), prenatal genetic testing (PGT) has been offered to detect various genomic disorders, including ASD, in Taiwan. However, disparities exist in this area, as there is limited research on factors associated with PGT utilization and relevant decision-making that may guide the regulations and ethical guidelines for culturally appropriate PGT services in Taiwan. This study proposed a comprehensively integrated theoretical framework for examining the intention to undergo PGT to detect ASD susceptibility genes and subsequent abortion decision-making among Taiwanese mothers of children affected by ASD. Survey data from 333 mothers of children with ASD in 236 elementary schools with special education services in Taiwan were collected and analyzed using structural equation modeling. Approximately two-thirds of the participants (66.6%) would undergo PGT to detect ASD susceptibility genes; more than half (53.1%) would terminate the hypothetically ASD-affected pregnancy. Abortion intention was associated with age, religion, attitudes toward PGT for detecting ASD susceptibility genes, and willingness to undergo such PGT. This study explores the potential impacts of PGT on Taiwanese society, and the findings are applicable to countries heavily influenced by Chinese culture, areas with Asian immigrants, and Western countries with such PGT services and/or research available.

Indexed as

Genetic Predisposition to DiseaseNoninvasive Prenatal TestingAbortion, InducedAdultAsian PeopleAutism Spectrum DisorderDecision MakingFemaleHumansInfant, NewbornMaleMothersPregnancySurveys and QuestionnairesTaiwanabortionautism spectrum disordersmothersprenatal genetic testingstructural equation modelingTaiwantermination of pregnancy

Identifiers

PMID31940763
PMCPMC7013751
OpenAlexW3000516804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.