Evidence map›Paper›PMID 31940754›Full record

ArticleInternational journal of molecular sciences2020

Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1β Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration.

Yun Gao, Dezhen Tu, Ru Yang, Chun-Hsien Chu, Jau-Shyong Hong, Hui-Ming Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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  13. Differentiation and regulation of CD4Cellular and molecular life sciences : CMLS · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yun GaoMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Institute for Brain Sciences, Nanjing University, Nanjing 210061, China.
Dezhen TuMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Institute for Brain Sciences, Nanjing University, Nanjing 210061, China.
Ru YangMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Institute for Brain Sciences, Nanjing University, Nanjing 210061, China.
Chun-Hsien ChuLaboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0003-2934-2584
Jau-Shyong HongLaboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC 27709, USA.
Hui-Ming GaoMOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Institute for Brain Sciences, Nanjing University, Nanjing 210061, China.ORCID 0000-0002-1349-9029
National Institutes of Health · USModel Animal Research Center · CN

Funding

Fundamental Research Funds for the Central Universities 14913101 and 1480601101high-level innovative and entrepreneurial talents of Jiangsu Province of China 2013Intramural Research Program of the NIH/NIEHS in the United States ES09008National Basic Research Program of China 2015BAI08B02national high technology research and development program of China 2014AA021601National Natural Science Foundation of China 21577004National Natural Science Foundation of China 31471006Priority Academic Program Development of Jiangsu Higher Education Institutions 0000
6 · The paper itself

Abstract

Chronic neuroinflammation contributes to the pathogenesis of Parkinson's disease (PD). However, cellular and molecular mechanisms by which chronic neuroinflammation is formed and maintained remain elusive. This study aimed to explore detailed mechanisms by which anti-inflammatory cytokine interleukin-10 (IL-10) prevented chronic neuroinflammation and neurodegeneration. At 24 h after an intranigral injection of lipopolysaccharide (LPS), levels of NLRP3, pro-caspase-1, pro-IL-1β, active caspase-1, and mature IL-1β in the midbrain were much higher in IL-10

Indexed as

AnimalsCaspase 1Cells, CulturedDopaminergic NeuronsFemaleInterleukin-10Interleukin-1betaLipopolysaccharidesMaleMiceMice, Inbred C57BLMicrogliaNADPH Oxidase 2NLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen SpeciesSubstantia NigraCaspase 1Cybb protein, mouseInterleukin-10Interleukin-1betaLipopolysaccharidesNADPH Oxidase 2NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReactive Oxygen SpeciesIL-10IL-1βneuroinflammationNLRP3 inflammasomeParkinson’s diseaseROS

Identifiers

PMID31940754
PMCPMC7013455
OpenAlexW2999351938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.