ArticleCell reports2020
Hippocampal Ripple Coordinates Retrosplenial Inhibitory Neurons during Slow-Wave Sleep.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- The default mode network exhibits circuit-specific selective vulnerability despite widespread amyloid burden in an animal model of Alzheimer's disease.Nature communications · 2026Article
- Anterior cingulate cortex monitors action state and action content in complex associative learning.eLife · 2026Article
- Article
- Epileptiform Discharges Drive Unique High-frequency Oscillations Within the Retrosplenial Cortex of Mice with Third Trimester Alcohol Exposure.bioRxiv : the preprint server for biology · 2026Article
- Role of the hippocampus in systems consolidation of remote fear memory.Experimental & molecular medicine · 2026Review
- Hippocampal synchrony dynamically gates cortical connectivity across brain states.Scientific reports · 2026Article
- Layer 1 NDNF interneurons form distinct subpopulations with opposite activation patterns during sleep in freely behaving mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Distinct Electrophysiological Signatures Define Neuronal Subtypes in the Fasciola Cinereum.bioRxiv : the preprint server for biology · 2025Article
- A Distinct Down-to-Up Transition Assembly in the Retrosplenial Cortex during Slow-Wave Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Inferring directed spectral information flow between mixed-frequency time series.Research square · 2025Article
- Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations.bioRxiv : the preprint server for biology · 2024Article
- Coordinated Interactions between the Hippocampus and Retrosplenial Cortex in Spatial Memory.Research (Washington, D.C.) · 2024Article
- Hippocampal memory reactivation during sleep is correlated with specific cortical states of the retrosplenial and prefrontal cortices.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Article
- How our understanding of memory replay evolves.Journal of neurophysiology · 2023Review
- The two tales of hippocampal sharp-wave ripple content: The rigid and the plastic.Progress in neurobiology · 2023Review
- Review
- Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice.eLife · 2023Article
- Alpha-synuclein oligomers alter the spontaneous firing discharge of cultured midbrain neurons.Frontiers in cellular neuroscience · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The hippocampus and retrosplenial cortex (RSC) play indispensable roles in memory formation, and importantly, a hippocampal oscillation known as ripple is key to consolidation of new memories. However, it remains unclear how the hippocampus and RSC communicate and the role of ripple oscillation in coordinating the activity between these two brain regions. Here, we record from the dorsal hippocampus and RSC simultaneously in freely behaving mice during sleep and reveal that the RSC displays a pre-ripple activation associated with slow and fast oscillations. Immediately after ripples, a subpopulation of RSC putative inhibitory neurons increases firing activity, while most RSC putative excitatory neurons decrease activity. Consistently, optogenetic stimulation of this hippocampus-RSC pathway activates and suppresses RSC putative inhibitory and excitatory neurons, respectively. These results suggest that the dorsal hippocampus mainly inhibits RSC activity via its direct innervation of RSC inhibitory neurons, which overshadows the RSC in supporting learning and memory functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.