ArticleCell reports2020
Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Spatial risks of Orthoebolavirus spillover vary based on outbreak type.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Article
- Comparison of the biological properties of bat-derived filovirus envelope glycoproteins.Journal of virology · 2025Article
- Where is the elusive primaryBioscience · 2025Article
- Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning.Cell host & microbe · 2025Article
- Article
- Molecular determinants of cross-species transmission in emerging viral infections.Microbiology and molecular biology reviews : MMBR · 2024Review
- Isolation, characterization, and circulation sphere of a filovirus in fruit bats.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Determination of the factors responsible for the tropism of SARS-CoV-2-related bat coronaviruses toJournal of virology · 2023Article
- Isolation and genome characterization of Lloviu virus from Italian Schreibers's bats.Scientific reports · 2023Article
- Traits, phylogeny and host cell receptors predict Ebolavirus host status among African mammals.PLoS neglected tropical diseases · 2022Article
- Emerging viruses: Cross-species transmission of coronaviruses, filoviruses, henipaviruses, and rotaviruses from bats.Cell reports · 2022Review
- Article
- Isolation of infectious Lloviu virus from Schreiber's bats in Hungary.Nature communications · 2022Article
- Distinct interferon response in bat and other mammalian cell lines infected with Pteropine orthoreovirus.Virus genes · 2021Article
- Cross-Neutralisation of Novel Bombali Virus by Ebola Virus Antibodies and Convalescent Plasma Using an Optimised Pseudotype-Based Neutralisation Assay.Tropical medicine and infectious disease · 2021Article
- Article
- Molecular Mechanisms Underlying the Cellular Entry and Host Range Restriction of Lujo Virus.mBio · 2021Article
- Receptor-Mediated Host Cell Preference of a Bat-Derived Filovirus, Lloviu Virus.Microorganisms · 2020Article
- Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment.International journal of antimicrobial agents · 2020Article
- Article
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species. Here, we show a molecular basis underlying the host-range restriction of filoviruses. We find that bat-derived cell lines FBKT1 and ZFBK13-76E show preferential susceptibility to EBOV and MARV, respectively, whereas the other bat cell lines tested are similarly infected with both viruses. In FBKT1 and ZFBK13-76E, unique amino acid (aa) sequences are found in the Niemann-Pick C1 (NPC1) protein, one of the cellular receptors interacting with the filovirus glycoprotein (GP). These aa residues, as well as a few aa differences between EBOV and MARV GPs, are crucial for the differential susceptibility to filoviruses. Taken together, our findings indicate that the heterogeneity of bat NPC1 orthologs is an important factor controlling filovirus species-specific host tropism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.