Observational studyPloS one2020
Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study.
Observational study in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of heart rate variability and menopausal vasomotor symptoms.Physiological reports · 2026Pooled it
- Regular postexercise sauna bathing does not improve heart rate variability: A multi-arm randomized controlled trial.Physiological reports · 2025Trial
- Cardiometabolic Health During the Climacteric Transition: A Narrative Review of Lifestyle, Physiological, and Nutritional Approaches.Healthcare (Basel, Switzerland) · 2026Review
- Vasomotor symptoms of menopause, sympathetic activity, and blood pressure in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2025Article
- Age predominates as associate than reproductive health stage for 5 min heart rate variability in middle aged women- a cross-sectional study from Gujarat, India.Journal of family medicine and primary care · 2025Article
- Heart Rate Variability in Relation to Cardiovascular Autonomic Neuropathy Among Patients at an Urban Hospital in Kazakhstan.International journal of environmental research and public health · 2024Article
- Do heart rate variability indices present potential to predict late postmenopausal? A retrospective study.Revista da Associacao Medica Brasileira (1992) · 2022Observational
- Article
- Association of Vasomotor Symptoms and Cardiac Autonomic Functions in Perimenopausal Women.Journal of mid-life healthArticle
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart Rate Variability (HRV) represents cardiac autonomic behavior and have been related to menopausal symptoms, mainly vasomotor symptoms and their imbalance to cardiovascular risk. It is not clear in the literature which index represents this imbalance and what is their involvement with the menopausal state. The aim of this study was to evaluate HRV in menopausal transition and post-menopausal symptoms with different intensities. This cross-sectional study was conducted in Rio Branco, State of Acre, Brazil from October 2016 to July 2017. We used Kupperman-Blatt Menopausal Index (KMI) to measure menopausal symptoms intensity. HRV analysis was performed based on the guidelines of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. HRV is lower in the group with moderate/intense menopausal symptoms compared to mild symptoms. (RMSSD: p = 0.005, Cohen's d = 0.53, pNN50: p = 0.0004, Cohen's d = 0.68; HF: p = 0.024, Cohen's d = 0.44). There was association between HRV and KMI (RMSSD: r = -1.248, p = 0.004; and pNN50: r = -0.615, p: 0.029) in inverse relation to the intensity of vasomotor symptoms in women in TM. In conclusion, HRV was able to distinguish menopausal symptoms, indicating reduced vagal control in women with more intense symptoms.
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