ArticleJournal of neurophysiology2020
Indirect pathway control of firing rate and pattern in the substantia nigra pars reticulata.
Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Synaptic integration and competition in the substantia nigra pars reticulata-An experimental and in silico analysis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neuronal and network resonance in the external globus pallidus.Journal of neurophysiology · 2025Article
- Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Impact of Unitary Synaptic Inhibition on Spike Timing in Ventral Tegmental Area Dopamine Neurons.eNeuro · 2024Article
- Dopamine depletion weakens direct pathway modulation of SNr neurons.Neurobiology of disease · 2024Article
- Comparison of unitary synaptic currents generated by indirect and direct pathway neurons of the mouse striatum.Journal of neurophysiology · 2024Article
- Article
- Propagation of Oscillations in the Indirect Pathway of the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Spontaneous Activity of the Local GABAergic Synaptic Network Causes Irregular Neuronal Firing in the External Globus Pallidus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Transmission of delta band (0.5-4 Hz) oscillations from the globus pallidus to the substantia nigra pars reticulata in dopamine depletion.Journal of computational neuroscience · 2022Article
- Local inhibition in a model of the indirect pathway globus pallidus network slows and deregularizes background firing, but sharpens and synchronizes responses to striatal input.Journal of computational neuroscience · 2022Article
- The mouse cortico-basal ganglia-thalamic network.Nature · 2021Article
- Distinct globus pallidus circuits regulate motor and cognitive functions.Trends in neurosciences · 2021Article
- Periodic unitary synaptic currents in the mouse globus pallidus during spontaneous firing in slices.Journal of neurophysiology · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Unitary pallido-nigral synaptic currents were measured using optogenetic stimulation, which activated up to three unitary synaptic inputs to each substantia nigra pars reticulata (SNr) cell. Episodic barrages of synaptic conductances were generated based on in vivo firing patterns of globus pallidus pars externa (GPe) cells and applied to SNr cells using conductance clamp. Barrage inputs were compared to continuous step conductances with the same mean. Barrage inputs and steps both slowed SNr neuron firing and produced disinhibition responses seen in peristimulus histograms. Barrages were less effective than steps at producing inhibition and disinhibition responses. Barrages, but not steps, produced irregular firing during the inhibitory response. Phase models of SNr neurons were constructed from their phase-resetting curves. The phase models reproduced the inhibition and disinhibition responses to the same inputs applied to the neurons. The disinhibition response did not require rebound currents but arose from reset of the cells' oscillation. The differences in firing rate and irregularity in response to barrage and step inhibition resulted from the high sensitivity of SNr neurons to inhibition at late phases in their intrinsic oscillation. During step inhibition, cells continued rhythmic firing at a reduced rate. During barrages, brief bouts of intense inhibition stalled the cells' phase evolution late in their cycle, close to firing, and even very brief respites from inhibition rapidly released single action potentials. The SNr cell firing pattern reflected the fine structure of the synaptic barrage from GPe, as well as its onset and offset.
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