ArticleEnvironmental health perspectives2020
Trihalomethanes in Drinking Water and Bladder Cancer Burden in the European Union.
Article in Environmental health perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.
- Burden of disease from contaminated drinking water in countries with high access to safely managed water: A systematic review.Water research · 2023Pooled it
- Seasonal forecasting of dissolved organic carbon in a Mediterranean catchment: Enhancing upstream control of disinfection by-product precursors.Environmental monitoring and assessment · 2026Article
- Disinfection Byproducts Confirmed over 50 Years: Systematic Curation, Modes of Toxic Action, and Toxicogenomics.Environmental science & technology · 2025Review
- Multipathway health risk assessment on disinfection byproducts of drinking water in central China: a study of 15,280 samples.Journal of water and health · 2025Article
- Review
- Haloacetonitriles Induce Structure-Related Cellular Toxicity Through Distinct Proteome Thiol Reaction Mechanisms.ACS environmental Au · 2025Article
- Health risk assessment via ingestion of disinfection by-products in drinking water.Scientific reports · 2025Article
- Article
- Adsorption Behavior and Mechanisms of Trihalomethanes onto Virgin and Weathered Polyvinyl Chloride Microplastics.Toxics · 2024Article
- Association of Domestic Water Hardness with All-Cause and Cause-Specific Cancers: Evidence from 447,996 UK Biobank Participants.Environmental health perspectives · 2024Article
- Global burden of bladder cancer mortality in 2020 and 2040 according to GLOBOCAN estimates.World journal of urology · 2024Article
- Chloroform exposure in air and water in Swedish indoor swimming pools-urine as a biomarker of occupational exposure.Annals of work exposures and health · 2023Article
- Nitrates and Prostate Cancer: Long-Term Drinking Water Exposures Associated with Risk of Tumors.Environmental health perspectives · 2023Article
- Prenatal exposure to tap water containing nitrate and the risk of small-for-gestational-age: A nationwide register-based study of Danish births, 1991-2015.Environment international · 2023Article
- Global assessment of chemical quality of drinking water: The case of trihalomethanes.Water research · 2023Article
- Bibliometric analysis of the association between drinking water pollution and bladder cancer.Frontiers in oncology · 2023Article
- Estimating National Exposures and Potential Bladder Cancer Cases Associated with Chlorination DBPs in U.S. Drinking Water.Environmental health perspectives · 2022Article
- Genetic variants in choline metabolism pathway are associated with the risk of bladder cancer in the Chinese population.Archives of toxicology · 2022Article
- Association of blood trihalomethane concentrations with asthma in US adolescents: nationally representative cross-sectional study.The European respiratory journal · 2022Article
- Identifying Novel Causes of Cancers to Enhance Cancer Prevention: New Strategies Are Needed.Journal of the National Cancer Institute · 2022Article
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Authors and funding
30 authors at 20 institutions in 18 countries.
Funding
Abstract
backgroundTrihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk.
objectiveWe assessed THM levels in drinking water in the European Union as a marker of DBP exposure and estimated the attributable burden of bladder cancer.
methodsWe collected recent annual mean THM levels in municipal drinking water in 28 European countries (EU28) from routine monitoring records. We estimated a linear exposure-response function for average residential THM levels and bladder cancer by pooling data from studies included in the largest international pooled analysis published to date in order to estimate odds ratios (ORs) for bladder cancer associated with the mean THM level in each country (relative to no exposure), population-attributable fraction (PAF), and number of attributable bladder cancer cases in different scenarios using incidence rates and population from the Global Burden of Disease study of 2016.
resultsWe obtained 2005-2018 THM data from EU26, covering 75% of the population. Data coverage and accuracy were heterogeneous among countries. The estimated population-weighted mean THM level was DISCUSSION: Efforts have been made to reduce THM levels in the European Union. However, assuming a causal association, current levels in certain countries still could lead to a considerable burden of bladder cancer that could potentially be avoided by optimizing water treatment, disinfection, and distribution practices, among other possible measures. https://doi.org/10.1289/EHP4495.
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