Evidence map›Paper›PMID 31939594›Full record

ArticleActa cirurgica brasileira2020

Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats.

Lízia Daniela E Silva Nascimento, Renata Amadei Nicolau, Antônio Luiz Martins Maia Filho, José Zilton Lima Verde Santos, Khetyma Moreira Fonseca, Danniel Cabral Leão Ferreira, Rayssilane Cardoso de Sousa, Vicente Galber Freitas Viana, Luiz Fernando Meneses Carvalho, José Figueredo-Silva

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Evaluation of How Methacrylate Gelatin Hydrogel Loaded withJournal of functional biomaterials · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Lízia Daniela E Silva NascimentoFellow PhD degree, Postgraduate Program in Biomedical Engineering, Universidade do Vale do Paraíba (UNIVAP), Sao Jose dos Campos-SP. Assistant Professor of Kinesiology, MSc, Health Sciences Center, Physical Therapy, Universidade Estadual do Piauí (UESPI), Teresina-PI, Brazil. Conception, design, intellectual and scientific content of the study; acquisition and interpretation of data; technical procedures; manuscript preparation.ORCID http://orcid.org/0000-0001-5837-8311
Renata Amadei NicolauPhD, Collaborator, Postgraduate Program in Biomedical Engineering of the Research and Development Institute, UNIVAP, Sao Jose dos Campos-SP, Brazil. Conception, design, intellectual and scientific content of the study; interpretation of data; critical revision.ORCID http://orcid.org/0000-0002-7687-7963
Antônio Luiz Martins Maia FilhoAssociate Professor of Physiology, Health Sciences Center, UESPI, Teresina-PI, Brazil. Technical procedures.ORCID http://orcid.org/0000-0001-6184-8003
José Zilton Lima Verde SantosMSc, Assistant Professor, Center of Health Sciences, Medicine and Physical Therapy, UESPI, Teresina-PI. Brazil. Histopathological examinations.ORCID http://orcid.org/0000-0001-9877-1994
Khetyma Moreira FonsecaFellow PhD degree, Postgraduate Program in Pharmacology, Universidade Federal do Ceará (UFC), Fortaleza-CE. MSc in Biotechnology, Northeast Biotechnology Network - RENORBIO, Teresina-PI, Brazil. Acquisition of data, statistical analysis.ORCID http://orcid.org/0000-0003-3722-4975
Danniel Cabral Leão FerreiraFellow Master degree, Professional Master's Program in Human and Animal Biotechnology MPBiotec, UESPI, Teresina-PI, Brazil. Technical procedures.ORCID http://orcid.org/0000-0002-0717-2900
Rayssilane Cardoso de SousaFellow PhD degree, Postgraduate Program in Biotechnology, Universidade Federal do Piauí (UFPI), Teresina-PI, Brazil. Membrane production.ORCID http://orcid.org/0000-0003-4244-1560
Vicente Galber Freitas VianaPhD, Associate Professor, Postgraduate Program in Material Engineering (PPGEM), Federal Institute of Education, Science and Technology of Piaui, IFPI, Teresina-PI, Brazil. Membrane production.ORCID http://orcid.org/0000-0002-3863-6974
Luiz Fernando Meneses CarvalhoPhD, Full Professor, Postgraduate Program in Material Engineering (PPGEM), Federal Institute of Education, Science and Technology of Piaui, IFPI, Teresina-PI, Brazil. Membrane production.ORCID http://orcid.org/0000-0002-1032-0230
José Figueredo-SilvaPhD, Associate Professor of Pathology, Health Sciences Center, UESPI, Teresina-PI, Brazil. Histopathological examinations, critical revision.ORCID http://orcid.org/0000-0002-7117-8784
Universidade Estadual do Piauí · BRInstituto Federal do Piauí · BRUniversidade do Vale do Paraíba · BRUniversidade Federal do Ceará · BRUniversidade Federal do Piauí · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair.

methodsThirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further subdivided into three subgroups (days 7, 14, and 21; n = 5 each). Samples were analyzed histologically.

resultsHistological analysis showed a significant reduction in inflammatory infiltrates on days 7, 14 (p < 0.0001 for both), and 21 (p = 0.0004) in the membrane group compared to that in the control group. There was also a significant decrease in the number of fibroblasts in the control group on days 7, 14 (p < 0.0001), and 21 (p = 0.0032). Further, an increase in type I collagen deposition was observed in the membrane group compared to that in the control group on days 7 (p = 0.0133) and 14 (p = 0.0107).

conclusionTreatment with norbixin-based PHB membranes reduces the inflammatory response, increases fibroblast proliferation, and improves collagen production in the tendon repair region, especially between days 7 and 14.

Indexed as

Achilles TendonAnimalsCarotenoidsCollagen Type ICollagen Type IIIFibroblastsHumansHydroxybutyratesMalePolyestersPolyhydroxybutyratesProhibitinsRats, WistarReference ValuesRegenerationReproducibility of ResultsCarotenoidsCollagen Type ICollagen Type IIIHydroxybutyratesnorbixinPHB protein, humanPhb protein, ratpoly-beta-hydroxybutyratePolyestersPolyhydroxybutyratesProhibitins

Identifiers

PMID31939594
PMCPMC6958576
OpenAlexW2999259782

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.