ArticleSao Paulo medical journal = Revista paulista de medicina
Fetal structural anomalies diagnosed during the first, second and third trimesters of pregnancy using ultrasonography: a retrospective cohort study.
Article in Sao Paulo medical journal = Revista paulista de medicina. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Detection of fetal structural abnormalities at 20 and 30 weeks: a retrospective study of prenatal ultrasound screening.Journal of medical ultrasonics (2001) · 2026Article
- Development and temporal validation of a multimodal post-test risk stratification model for pregnancies with abnormal prenatal findings.Scientific reports · 2026Article
- Moderate Diagnostic Yield of Exome Sequencing in Fetal Growth Restriction: Retrospective Insights.Prenatal diagnosis · 2026Article
- Integrated genomic and clinical indicators for predicting foetal chromosomal abnormalities: development and validation of a nomogram model.Journal of global health · 2026Article
- Clinical outcomes after nondiagnostic prenatal exome sequencing: Need for balancing reassurance and residual risks in genetic counseling.Journal of genetic counseling · 2026Article
- A case report of complete penoscrotal transposition and associated anomalies in a newborn.International journal of surgery case reports · 2025Article
- Application of an individualized nomogram in the first-trimester for predicting cleft lip and palate.BMC pregnancy and childbirth · 2025Article
- Article
- Evaluation of Spousal Support and Stress Coping Styles of Pregnant Women Diagnosed with Fetal Anomaly.Medicina (Kaunas, Lithuania) · 2025Article
- Analysis of fatal congenital anomalies among pregnant women at Saudi Arabia using ultrasonography.Bioinformation · 2025Article
- Antenatally diagnosed myelomeningocele with associated chiari ii malformation in the third trimester. A case report.Radiology case reports · 2024Article
- Correlation between fetal ventricular echogenic foci in pregnancy and fetus chromosomal anomaly: a case-control study in Bandar Abbas city.Annals of medicine and surgery (2012) · 2024Article
- Review
- Role of autopsy in diagnosing asplenia and right bilobed lung in a fetus with dextrocardia.BMJ case reports · 2023Article
- Evaluation of prenatal central nervous system anomalies: obstetric management, fetal outcomes and chromosome abnormalities.BMC pregnancy and childbirth · 2022Article
- Clinical efficiency of simultaneous CNV-seq and whole-exome sequencing for testing fetal structural anomalies.Journal of translational medicine · 2022Article
- Worm Sign: A possible first-trimester sonographic marker for intracranial haemorrhage resulting in significant cortical disruption.Australasian journal of ultrasound in medicine · 2021Article
- Prevalence of associated extracardiac anomalies in prenatally diagnosed congenital heart diseases.PloS one · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of congenital abnormalities in general populations is approximately 3-5%. One of the most important applications of obstetric ultrasound is in detection of fetal structural defects.
objectiveTo assess fetal structural anomalies diagnosed using ultrasound in the three trimesters of pregnancy. DESIGN AND
settingRetrospective cohort study at the Mário Palmério University Hospital of the University of Uberaba (Universidade de Uberaba, UNIUBE), from March 2014 to December 2016.
methodsUltrasound data at gestational weeks 11-13 + 6, 20-24 and 32-36 were recorded to identify fetal anomalies in each trimester and in the postnatal period. The primary outcome measurements were sensitivity, specificity, positive predictive value and negative predictive value for detection of fetal anomalies and their prevalence.
resultsThe prevalence of anomalies detected using ultrasound was 2.95% in the prenatal period and 7.24% in the postnatal period. The fetal anomalies most frequently diagnosed using ultrasound in the three trimesters were genitourinary tract anomalies, with a prevalence of 27.8%. Cardiac anomalies were diagnosed more often in the postnatal period, accounting for 51.0% of all cases. High specificity, negative predictive value and accuracy of ultrasound were observed in all three trimesters of pregnancy.
conclusionUltrasound is safe and has utility for detecting fetal anomalies that are associated with high rates of morbidity and mortality. However, the low sensitivity of ultrasound for detecting fetal anomalies in unselected populations limits its utility for providing reassurance to examiners and to pregnant women with normal results.
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