Evidence map›Paper›PMID 31939157›Full record

ReviewSub-cellular biochemistry2019

Biology and Biochemistry of Bacterial Proteasomes.

Samuel H Becker, Huilin Li, K Heran Darwin

Abstract readReview
In one paragraph

Review in Sub-cellular biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samuel H BeckerDepartment of Microbiology, New York University School of Medicine, 430 E. 29th Street, Room 312, New York, NY, 10016, USA.
Huilin LiVan Andel Research Institute, Cryo-EM Structural Biology Laboratory, 333 Bostwick Ave, NE, Grand Rapids, MI, 4950, USA.
K Heran DarwinDepartment of Microbiology, New York University School of Medicine, 430 E. 29th Street, Room 312, New York, NY, 10016, USA. heran.darwin@med.nyu.edu.

Funding

INFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9M
PROTEASOME-DEPENDENT DEGRADATION IN MYCOBACTERIUM TUBERCULOSISR01AI088075 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Katerina Heran Darwin · 2011 to 2026
$6.5M
Structure Biology of Mycobacterium Tuberculosis Pup-Proteasome PathwayR01AI070285 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI LI, HUILIN · 2007 to 2022
$6.5M
Virulence Regulation by the Mycobacterium Tuberculosis ProteasomeR01HL092774 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DARWIN, KATERINA HERAN · 2007 to 2017
$4.0M
NHLBI NIH HHS R01 HL092774NIAID NIH HHS R01 AI070285NIAID NIH HHS R01 AI088075NIAID NIH HHS T32 AI007180
6 · The paper itself

Abstract

Proteasomes are a class of protease that carry out the degradation of a specific set of cellular proteins. While essential for eukaryotic life, proteasomes are found only in a small subset of bacterial species. In this chapter, we present the current knowledge of bacterial proteasomes, detailing the structural features and catalytic activities required to achieve proteasomal proteolysis. We describe the known mechanisms by which substrates are doomed for degradation, and highlight potential non-degradative roles for components of bacterial proteasome systems. Additionally, we highlight several pathways of microbial physiology that rely on proteasome activity. Lastly, we explain the various gaps in our understanding of bacterial proteasome function and emphasize several opportunities for further study.

Indexed as

BacteriaBacterial ProteinsProteasome Endopeptidase ComplexProteolysisBacterial ProteinsProteasome Endopeptidase ComplexMycobacteriumProteasomeProteolysisPupylation

Identifiers

PMID31939157
PMCPMC7155931

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.