Evidence map›Paper›PMID 31939081›Full record

ArticleJournal of autism and developmental disorders2021

Screening for Behavioral Signs of Autism Spectrum Disorder in 9-Month-Old Infant Siblings.

Lori-Ann R Sacrey, Lonnie Zwaigenbaum, Susan Bryson, Jessica Brian, Isabel M Smith, Wendy Roberts, Peter Szatmari, Tracy Vaillancourt, Caroline Roncadin, Nancy Garon

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In one paragraph

Article in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study.Autism research : official journal of the International Society for Autism Research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lori-Ann R SacreyDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada. sacrey@ualberta.ca.ORCID http://orcid.org/0000-0002-4229-6933
Lonnie ZwaigenbaumDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Susan BrysonDalhousie University/IWK Health Centre, Halifax, NS, Canada.
Jessica BrianBloorview Research Institute, Toronto, ON, Canada.
Isabel M SmithDalhousie University/IWK Health Centre, Halifax, NS, Canada.
Wendy RobertsISAND, Toronto, ON, Canada.
Peter SzatmariUniversity of Toronto, Toronto, ON, Canada.
Tracy VaillancourtUniversity of Ottawa, Ottawa, ON, Canada.
Caroline RoncadinUniversity of Toronto, Toronto, ON, Canada.
Nancy GaronMount Allison University, Sackville, NB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite considerable progress in characterizing the early signs of autism spectrum disorder (ASD), more remains to be learned about how symptoms emerge in the first year of life. Parents with a new baby who already had at least one biological child diagnosed with ASD (high-risk) or no family history of ASD (low-risk) completed two measures when their baby was 9 months of age, the Autism Parent Screen for Infants (APSI) questionnaire and the interview-based Parent Concerns Form. Children underwent a blinded independent diagnostic assessment for ASD at age 3 years. Total scores on the APSI and the Parent Concerns Form were both able to independently differentiate high-risk children who were later diagnosed with ASD from other high-risk and low-risk children who were not. Using logistic regression, we found that the total score on the APSI predicted ASD outcomes at age 3 with 70% accuracy, but the Parent Concerns Form did not contribute any unique variance when the APSI was already in the model. The results suggest that the APSI identifies early features predictive of ASD in high-risk infants and can be used to flag them for targeted follow-up and screening.

Indexed as

SiblingsAutism Spectrum DisorderChildChild, PreschoolFemaleHumansInfantMaleParentsRiskAutism spectrum disorderEarly detectionHigh-risk siblingsParent reportProspectiveScreening

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.