ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020
SPECT/CT imaging of lower extremity perfusion reserve: A non-invasive correlate to exercise tolerance and cardiovascular fitness in patients undergoing clinically indicated myocardial perfusion imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Quantification of Skeletal Muscle Perfusion in Peripheral Artery Disease UsingJournal of the American Heart Association · 2024Trial
- Contrast enhanced ultrasound and laser doppler flowmetry capture distinct aspects of tissue microvascular perfusion in nonhuman primates.Physiological reports · 2026Article
- Quantification of Skeletal Muscle Perfusion in Feet and Lower Legs of Patients with T2DM and Diabetic Foot Ulcers Using [Journal of clinical medicine · 2025Article
- Lower Extremity Flow Quantification Using DynamicIEEE transactions on radiation and plasma medical sciences · 2025Article
- New horizons in nuclear cardiology: Imaging of peripheral arterial disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Review
- Clinical physiology: the crucial role of MRI in evaluation of peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2024Review
- The Potential Role of PET in the Management of Peripheral Artery Disease.Current cardiology reports · 2023Review
- Molecular Imaging of Lower Extremity Peripheral Arterial Disease: An Emerging Field in Nuclear Medicine.Frontiers in medicine · 2021Article
- SPECT/CT quantification of lower limb perfusion: The next frontier in radionuclide perfusion imaging?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
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Abstract
backgroundAlthough exercise is often prescribed for the management of cardiovascular diseases, a non-invasive imaging approach that quantifies skeletal muscle physiology and correlates with patients' functional capacity and cardiovascular fitness has been absent. Therefore, we evaluated the potential of lower extremity single photon emission computed tomography (SPECT)/CT perfusion imaging as a non-invasive correlate to exercise tolerance and cardiovascular fitness.
methodsPatients (n = 31) undergoing SPECT/CT myocardial perfusion imaging underwent additional stress/rest SPECT/CT imaging of the lower extremities. CT-based image segmentation was used for regional quantification of perfusion reserve within the tibialis anterior, soleus, and gastrocnemius muscles. Metabolic equivalents (METs) at peak exercise and heart rate recovery (HRR) after exercise were recorded.
resultsPeak METs were significantly associated with perfusion reserve of tibialis anterior (p = 0.02), soleus (p = 0.01) and gastrocnemius (p = 0.01). HRR was significantly associated with perfusion reserve of the soleus (p = 0.02) and gastrocnemius (p = 0.04) muscles. Perfusion reserve of the tibialis anterior (40.6 ± 20.2%), soleus (35.4 ± 16.7%), and gastrocnemius (29.7 ± 19.1%) all significantly differed from each other.
conclusionsSPECT/CT imaging provides regional quantification of skeletal muscle perfusion reserve which is significantly associated with exercise tolerance and cardiovascular fitness. Future application of SPECT/CT may elucidate the underlying skeletal muscle adapations to exercise therapy in patients with cardiovascular diseases.
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