ArticleAnnals of biomedical engineering2020
Numerical Study of Atrial Fibrillation Effects on Flow Distribution in Aortic Circulation.
Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Effects of Ageing on Aortic Circulation During Atrial Fibrillation; a Numerical Study on Different Aortic Morphologies.Annals of biomedical engineering · 2021Pooled it
- Developing a non-invasive diagnostic framework for the fractional flow reserve quantification in left coronary arteries: validation with patient cases.Frontiers in physiology · 2026Article
- An in silico analysis of heart rate impact on wall shear stress hemodynamic parameters in aortic coarctation.Scientific reports · 2025Article
- Echocardiographic assessment of left atrial appendage morphology and function-an expert proposal by the German Working Group of Cardiovascular Ultrasound.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Review
- Smoothed particle hydrodynamics based FSI simulation of the native and mechanical heart valves in a patient-specific aortic model.Scientific reports · 2024Article
- Enhancing the implantation of mechanical circulatory support devices using computational simulations.Frontiers in bioengineering and biotechnology · 2024Article
- Multi-Objective Optimisation of a Novel Bypass Graft with a Spiral Ridge.Bioengineering (Basel, Switzerland) · 2023Article
- Abnormal flow pattern of low wall shear stress and high oscillatory shear index in spontaneous vertebral artery dissection with vertebral artery hypoplasia.Frontiers in neuroscience · 2023Article
- The Differences of Quantitative Flow Ratio in Coronary Artery Stenosis with or without Atrial Fibrillation.Journal of interventional cardiology · 2023Article
- Cerebral hemodynamics during atrial fibrillation: Computational fluid dynamics analysis of lenticulostriate arteries using 7 T high-resolution magnetic resonance imaging.Physics of fluids (Woodbury, N.Y. : 1994) · 2022Article
- Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke.Frontiers in cardiovascular medicine · 2022Review
- Insights from computational modeling on the potential hemodynamic effects of sinus rhythm versus atrial fibrillation.Frontiers in cardiovascular medicine · 2022Review
- Development of a computational fluid dynamic model to investigate the hemodynamic impact of REBOA.Frontiers in physiology · 2022Article
- Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation.Wellcome open research · 2021Article
- A computational simulation platform for designing real-time monitoring systems with application to COVID-19.Biosensors & bioelectronics · 2021Article
- Numerical framework for simulating bio-species transport in microfluidic channels with application to antibody biosensors.MethodsX · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Atrial fibrillation (AF) is the most common type of arrhythmia, which undermines cardiac function. Atrial fibrillation is a multi-facet malady and it may occur as a result of other diseases or it may trigger other problems. One of the main complications of AF is stroke due to the possibility of clot formation inside the atrium. However, the possibility of stroke occurrence due to the AF and the location from which an embolus dispatches are subject of debate. Another hypothesis about the embolus formation during AF is thrombus formation in aorta and carotid arteries, embolus detachment and its movement. To investigate the possibility of the latter postulation, the current work suggests a parametric study to quantify the sensitivity of aortic flow to four common AF traits including lack of atrial kick, atrial remodelling, left ventricle systolic dysfunction, and high frequency fibrillation. The simulation was carried out by coupling several in-house codes and ANSYS-CFX module. The results reveal that AF traits lower flow rate at left ventricular outflow tract, which in general lowers blood perfusion to systemic, cerebral and coronary circulations. Consequently, it leads to endothelial cell activation potential (ECAP) increase and variation of flow structure that both suggest predisposed areas to atherogenesis and thrombus formation in different regions in ascending aorta, aortic arch and descending thoracic aorta.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.