Evidence map›Paper›PMID 31938978›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2020

Complexity analysis of heart rate variability in chronic obstructive pulmonary disease: relationship with severity and symptoms.

Nelson Francisco Serrão, Alberto Porta, Vinicius Minatel, Antônio A M Castro, Aparecida Maria Catai, Luciana Maria Malosá Sampaio, Ross Arena, Audrey Borghi-Silva

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Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Physiological signal entropy in patients with chronic respiratory disease: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
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  3. Review
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Polyunsaturated Fatty Acid EAB-277Frontiers in veterinary science · 2022
    Article
  10. Review
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nelson Francisco SerrãoPhysical Therapy Department, Federal University of Pampa, Uruguaiana, Brazil.
Alberto PortaDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Vinicius MinatelPhysical Therapy Department, University Center Tiradentes, Maceió, Brazil.
Antônio A M CastroPhysical Therapy Department, Federal University of Pampa, Uruguaiana, Brazil.ORCID 0000-0002-7323-0937
Aparecida Maria CataiCardiovascular Physical Therapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, Sao Paulo, Brazil.
Luciana Maria Malosá SampaioSleep Laboratory, Nove de Julho University (UNINOVE), Sao Paulo, Brazil.
Ross ArenaDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Audrey Borghi-SilvaCardiopulmonary Physical Therapy Laboratory (LACAP), Department of Physical Therapy, Federal University of São Carlos (UFSCar), Rodovia, Washington Luís, km 235, Bairro Monjolinho, São Carlos, SP, CEP 13565-905, Brazil. audrey@ufscar.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChronic obstructive pulmonary disease (COPD) negatively impacts autonomic control of the heart rate, as assessed by time and frequency domains of heart rate variability (HRV) analysis. However, it is unknown whether symbolic dynamic analysis may identify cardiac autonomic impairment, and whether such nonlinear indices may be associated with disease severity, prognostic markers, perceived dyspnea and functional capacity in patients with COPD. The current study assessed cardiac autonomic modulation by symbolic analysis of HRV in patients with COPD compared with healthy controls.

methodsWe recruited 54 COPD patients and 20 healthy controls. The interval between two successive R-wave peaks was calculated in the resting supine position. HRV was analyzed using symbolic markers and Shannon entropy (SE). The six-minute walk test (6MWT) was applied in a 30-m corridor.

resultsWe found a lower 6MWT distance in patients with COPD compared with healthy controls (p < 0.05). We found increased SE and decreased percentage of no variation patterns (0V%) in COPD patients compared with the control group (p = 0.001). Significant correlations were found between the percentage of one variation pattern (1V%) and the Medical Research Council dyspnea scale (r = 0.38, p = 0.01), BODE index (r = 0.38, p = 0.01), forced expiratory volume in the first second (FEV

conclusionCOPD patients present with depressed sympathetic modulation of HR and higher SE compared with healthy controls. This increased irregularity was inversely associated with 0V%. These results suggested that COPD patients seem to have a cardiac control shifted towards a parasympathetic predominance compared with controls. Symbolic dynamic and complexity index of HRV are related to disease severity, symptoms and functional impairment in these patients.

Indexed as

Severity of Illness IndexSystems AnalysisAgedAged, 80 and overElectrocardiographyExercise TestFemaleForced Expiratory VolumeHeart RateHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveRespiratory Function TestsWalk TestConditional entropyFunctional capacityRespiratory diseaseSymbolic analysis

Identifiers

PMID31938978

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.