Evidence map›Paper›PMID 31938892›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Human biodistribution and radiation dosimetry of [

Corinne Beinat, Chirag B Patel, Tom Haywood, Bin Shen, Lewis Naya, Harsh Gandhi, Dawn Holley, Mehdi Khalighi, Andrei Iagaru, Guido Davidzon and 1 more

Registry-linked trialAbstract readClinical Trial, Phase I
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03539731 (A Phase I Study of [18F]DASA-23 as a PET Tracer for Evaluating Pyruvate Kinase M2), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03539731 phase1terminatednot on this map

A Phase I Study of [18F]DASA-23 as a PET Tracer for Evaluating Pyruvate Kinase M2 (PKM2) Expression in Healthy Volunteers and in Patients With Intracranial Tumors

TypeinterventionalSponsorGuido A. Davidzon, MD, SMRan2018 to 2022Enrolled27ConditionsHealthy Subject, Intracranial Neoplasm, GlioblastomaArmsFluorine F 18 DASA-23, Positron Emission Tomography
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. [Neuroradiology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. A Clinical PET Imaging Tracer ([Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  10. Unconventional non-amino acidic PET radiotracers for molecular imaging in gliomas.European journal of nuclear medicine and molecular imaging · 2021
    Review
  11. Article
  12. Development of [Nuclear medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Corinne BeinatMolecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Chirag B PatelMolecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Tom HaywoodMolecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Bin ShenMolecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Lewis NayaDivision of Neuro-Oncology, Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Harsh GandhiMolecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Dawn HolleyMolecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Mehdi KhalighiMolecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Andrei IagaruDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Guido DavidzonDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Sanjiv Sam GambhirMolecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, 94305, USA. sgambhir@stanford.edu.ORCID 0000-0002-2711-7554
Stanford University · USStanford Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the safety, biodistribution, and radiation dosimetry of the novel positron emission tomography (PET) radiopharmaceutical 1-((2-fluoro-6-[[

methodsWe recruited 5 healthy volunteers who provided a written informed consent. Volunteers were injected with 295.0 ± 8.2 MBq of [

resultsAll subjects tolerated the PET/MRI examination, without adverse reactions to [

conclusionWe successfully completed a pilot first-in-human study of [

trial registrationClinicalTrials.gov , NCT03539731 (registered 28 May 2018).

Indexed as

Positron-Emission TomographyPyruvate KinaseDiazonium CompoundsHumansRadiometrySulfanilic AcidsTissue Distributiondiazobenzenesulfonic acidDiazonium CompoundsPyruvate KinaseSulfanilic Acids[18F]DASA-23BiodistributionFirst-in-humanPKM2Radiation dosimetry

Identifiers

PMID31938892
OpenAlexW2999613373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.