SynthesisJournal of neurology2020
A pooled meta-analysis of GPi and STN deep brain stimulation outcomes for cervical dystonia.
Synthesis in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Deep brain stimulation for severe dystonia associated with Wilson disease: A prospective multicenter meta-analysis of an N-of-1 trial.European journal of neurology · 2025Pooled it
- Mechanism and progress of deep brain stimulation in the treatment of neurological and psychiatric disorders.MedScience · 2026Review
- Pallidal Deep Brain Stimulation in Dystonia: Investigating Differential Response by Dystonia Distribution.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Beyond the Neck: Long-Term Motor and Non-motor Outcomes of Pallidal DBS in Craniocervical Dystonia.Dystonia (Lausanne, Switzerland) · 2026Article
- Optimal Stimulation Sites and Connectomes for GPi and STN-DBS in Cervical Dystonia.CNS neuroscience & therapeutics · 2025Article
- Development and application of a clinical core data set for deep brain stimulation in Parkinson's disease, dystonia or tremor: from data collection to data exchange and data sharing.Neurological research and practice · 2025Article
- Comparison of different surgical strategies for cervical dystonia: Evidence from Bayesian network analysis.European journal of neurology · 2025Article
- Isolated Idiopathic Cervical Dystonia with a Rare Type of Atlantoaxial Dislocation. A Case Report and a Short Literature Review.Orthopedic research and reviews · 2025Article
- Subthalamic nucleus deep brain stimulation in primary Meige syndrome: motor and non-motor outcomes.European journal of neurology · 2024Article
- Architecture of the subthalamic nucleus.Communications biology · 2024Review
- Article
- Electrophysiological insights into deep brain stimulation of the network disorder dystonia.Pflugers Archiv : European journal of physiology · 2023Review
- Exploring clinical outcomes in patients with idiopathic/inherited isolated generalized dystonia and stimulation of the subthalamic region.Arquivos de neuro-psiquiatria · 2023Article
- Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study.Neurological research and practice · 2022Article
- Pallidus Stimulation for Chorea-Acanthocytosis: A Systematic Review and Meta-Analysis of Individual Data.Journal of movement disorders · 2022Article
- Article
- Unilateral pallidothalamic tractotomy at Forel's field H1 for cervical dystonia.Annals of clinical and translational neurology · 2022Article
- Adjuvant medical therapy in cervical dystonia after deep brain stimulation: A retrospective analysis.Frontiers in neurology · 2022Article
- The inhibition mechanism of epilepsy disease in a computational model.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022Article
- Improvement of head and neck range of motion induced by chronic pallidal deep brain stimulation for cervical dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo analyze deep brain stimulation (DBS) outcomes in patients with cervical dystonia (CD), the relationships between motor and disability/pain outcomes, and the differences in outcomes between globus pallidus internus (GPi) and subthalamic nucleus (STN) DBS, and to identify potential outcome predictors.
methodsA systematic literature search identified individual patient data of CD patients who underwent DBS and whose outcomes were assessed with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Then, we performed a pooled meta-analysis on this cohort.
resultsA review of 39 papers yielded 208 patients with individual TWSTRS scores and demographic information. At a mean follow-up period of 23.3 months after either GPi or STN DBS, the TWSTRS total (58.8%), severity (53.9%), disability (61.3%), and pain (46.6%) scores significantly improved compared to baseline status (all p < 0.001). There were no significant outcome differences between short-term (< 23.3 months) and long-term (≥ 23.3 months). The TWSTRS outcomes after GPi and STN DBS were comparable, whereas these two targets showed different adverse effect profiles. The rates of responders to DBS according to the TWSTRS total and severity (defined as ≥ 25% improvement) were both 89%. Regression analyses demonstrated motor benefits associated with disability improvement more than pain relief (R
conclusionDBS improves motor symptoms, disability, and pain in CD patients and may provide sustained benefits over 2 years. GPi and STN appear to be equally effective targets with different adverse effect profiles.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.