Evidence map›Paper›PMID 31938858›Full record

ArticleInternational orthopaedics2020

While home chlorhexidine washes prior to shoulder surgery lower skin loads of most bacteria, they are not effective against Cutibacterium (Propionibacterium).

Frederick A Matsen, Anastasia J Whitson, Jason E Hsu

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in International orthopaedics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05701475 (Triple Prevention Against Cutibacterium Acnes Using Benzoyl Peroxide Preparation in Addition to Pre-operative Cutaneous and Subcutaneous Iodine in Shoulder Surgery; a Single-blinded, Randomized, Controlled Trial.), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05701475 nacompletednot on this mapstarted 2023, after this paper: background citation

Triple Prevention Against Cutibacterium Acnes Using Benzoyl Peroxide Preparation in Addition to Pre-operative Cutaneous and Subcutaneous Iodine in Shoulder Surgery; a Single-blinded, Randomized, Controlled Trial.

TypeinterventionalSponsorClinique Générale dAnnecyRan2023 to 2024Enrolled156ConditionsPost-Operative Wound Infection, Surgical Site InfectionArmsSubcutaneous disinfection, Benzoyl peroxide preparation
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Microorganisms · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Efficacy of antimicrobial washes before shoulder surgery againstJSES reviews, reports, and techniques · 2022
    Review
  10. Marking Pen Bacterial Contamination During Shoulder Surgery.Orthopaedic journal of sports medicine · 2022
    Article
  11. Periprosthetic Infection After Reverse Shoulder Arthroplasty: a Review.Current reviews in musculoskeletal medicine · 2020
    Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Frederick A MatsenDepartment of Orthopedic and Sports Medicines, University of Washington Medical Center, 1959 NE Pacific Street, Box 356500, Seattle, WA, 98195-6500, USA. matsen@uw.edu.ORCID http://orcid.org/0000-0002-6465-4826
Anastasia J WhitsonDepartment of Orthopedic and Sports Medicines, University of Washington Medical Center, 1959 NE Pacific Street, Box 356500, Seattle, WA, 98195-6500, USA.
Jason E HsuDepartment of Orthopedic and Sports Medicines, University of Washington Medical Center, 1959 NE Pacific Street, Box 356500, Seattle, WA, 98195-6500, USA.
University of Washington Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChlorhexidine showers prior to shoulder arthroplasty are commonly recommended by surgeons to lower the risk of periprosthetic infection; however, the effectiveness of these washes in eliminating bacteria from the skin of the shoulder has not been thoroughly evaluated. The objective of this study was to determine the degree to which pre-operative chlorhexidine washes effectively eliminate bacteria from the epidermal skin surface and from the dermis freshly incised during shoulder arthroplasty.

methodsAround 66 patients undergoing primary shoulder arthroplasty were instructed to shower with chlorhexidine before surgery. Each patient had three skin swabs: (1) the epidermis at a pre-operative clinic appointment, (2) the epidermis at surgery after home chlorhexidine showers but prior to skin preparation, and (3) the dermis after incision of the prepared skin. The bacterial loads of Cutibacterium and other bacterial types from each swab were compared to determine whether the showers were effective in altering the bacterial loads.

resultsChlorhexidine washes were effective in reducing the skin load of other bacterial species (p < 0.005), but they did not decrease the skin load of Cutibacterium (p = 0.585).

conclusionsPre-operative skin showers with chlorhexidine were not effective in reducing the load of Cutibacterium on the skin of patients having shoulder arthroplasty. Since Cutibacterium is responsible for the highest percentage of shoulder periprosthetic infections, research is needed to identify more effective means of removing these bacteria from the surgical field.

Indexed as

Arthroplasty, Replacement, ShoulderAgedAnti-Infective Agents, LocalBacteriaChlorhexidineFemaleHumansMaleMiddle AgedPreoperative CarePropionibacteriumPropionibacterium acnesProspective StudiesShoulder JointSkinSkin CareAnti-Infective Agents, LocalChlorhexidineCutibacteriumPropionibacteriumProsthetic joint infectionShoulder arthroplastySurgical prophylaxis

Identifiers

PMID31938858
OpenAlexW3000087205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.