Evidence map›Paper›PMID 31938857›Full record

ArticleEuropean journal of clinical pharmacology2020

Phenytoin intoxication associated with omeprazole administration in a child with defective CYP2C9.

M Marano, F Nicoletti, S Pro, B M Goffredo, C Cecchetti, E Piervincenzi, E Agolini, D Cocciadiferro

Abstract readCase ReportsLetter
PubMed Publisher
In one paragraph

Article in European journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

M MaranoDEA Paediatric Intensive Care Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy. marco.marano@opbg.net.ORCID http://orcid.org/0000-0002-7413-3194
F NicolettiDepartment of Physiology and Pharmacology, University Sapienza of Rome, Rome, Italy.
S ProNeurology Unit, Department of Neurosciences, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.
B M GoffredoDepartment of Pediatric Medicine, Laboratory of Metabolic Biochemistry Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.
C CecchettiDEA Paediatric Intensive Care Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
E PiervincenziDEA Paediatric Intensive Care Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
E AgoliniLaboratory of Medical Genetics, Bambino Gesù Children's Hospital, Rome, Italy.
D CocciadiferroLaboratory of Medical Genetics, Bambino Gesù Children's Hospital, Rome, Italy.
Bambino Gesù Children's Hospital · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse drug reactions occur at a high rate in hospitalized children, frequently due to antiepileptic drug administration. Phenytoin is a commonly used drug, and its metabolism is mediated by a specific cytochrome-P

Indexed as

Child, PreschoolCytochrome P-450 CYP2C19Cytochrome P-450 CYP2C9Drug InteractionsGenotypeHumansOmeprazolePhenytoinPolymorphism, GeneticCYP2C19 protein, humanCYP2C9 protein, humanCytochrome P-450 CYP2C19Cytochrome P-450 CYP2C9OmeprazolePhenytoinAdverse drug reactionsCYP2C19CYP2C9OmeprazolePhenytoin

Identifiers

PMID31938857
OpenAlexW3005329258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.