ArticleJournal of psychiatry and brain science2019
Improving Cognition via Exercise (ICE): Study Protocol for a Multi-Site, Parallel-Group, Single-Blind, Randomized Clinical Trial Examining the Efficacy of Aerobic Exercise to Improve Neurocognition, Daily Functioning, and Biomarkers of Cognitive Change in Individuals with Schizophrenia.
Article in Journal of psychiatry and brain science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03270098 (Improving Cognition Via Exercise in Schizophrenia), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Cognition Via Exercise in Schizophrenia
Who cites it
11 citing papers in PubMed.
- Telehealth-Based vs In-Person Aerobic Exercise in Individuals With Schizophrenia: Comparative Analysis of Feasibility, Safety, and Efficacy.JMIR mental health · 2025Trial
- Exercise behaviours and motivation after a first psychotic episode: A digital intervention.Early intervention in psychiatry · 2024Trial
- Exercise Intervention in Individuals at Clinical High Risk for Psychosis: Benefits to Fitness, Symptoms, Hippocampal Volumes, and Functional Connectivity.Schizophrenia bulletin · 2022Trial
- Enhancement of aerobic fitness improves social functioning in individuals with schizophrenia.European archives of psychiatry and clinical neuroscience · 2021Trial
- Childhood Trauma in People with Psychosis: Implications for Emotion Awareness and Regulation.Psychosis · 2025Article
- Assessing the inter-rater reliability of the Schizophrenia Cognition Rating Scale: a non-interventional quantitative study.Schizophrenia (Heidelberg, Germany) · 2025Article
- Physical and mental health in adolescence: novel insights from a transdiagnostic examination of FitBit data in the ABCD study.Translational psychiatry · 2024Article
- Physical and Mental Health in Adolescence: Novel Insights from a transdiagnostic examination of FitBit data in the ABCD Study.Research square · 2023Article
- A controlled open clinical trial of the positive effect of a physical intervention on quality of life in schizophrenia.Frontiers in psychiatry · 2023Article
- Psychosis risk individuals show poor fitness and discrepancies with objective and subjective measures.Scientific reports · 2021Observational
- BDNF as a Biomarker of Cognition in Schizophrenia/Psychosis: An Updated Review.Frontiers in psychiatry · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Individuals with schizophrenia (SZ) display cognitive deficits that have been identified as major determinants of poor functioning and disability, representing a serious public health concern and an important target for interventions. At present, available treatments offer only minimal to moderate benefits to ameliorate cognitive deficits. Thus, there remains an urgent need to identify novel interventions to improve cognition in people with SZ. Emerging evidence from animal and basic human research suggests aerobic exercise training (AE) has beneficial effects on cognition. Preliminary findings suggest that AE is efficacious in improving cognitive functioning in SZ, however the extant studies have been limited by small samples, a dearth of information on biologically-relevant covariates, and limited information on impact on daily functioning. Additionally, while AE-related cognitive benefits have been linked to Brain-Derived Neurotrophic Factor (BDNF) upregulation, this putative mechanism needs confirmation. The present report describes a study protocol designed to address these limitations-we review and summarize the current literature on treatment of cognitive deficits in SZ, state the rationale for employing AE to target these deficits, and describe the current protocol-a multi-site, single-blind, randomized clinical trial aiming to recruit 200 community-dwelling individuals with SZ. Participants are randomized to one of two 12-week interventions: AE using active-play video games (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.