ArticleJournal of exercise rehabilitation2019
Effects of preconditioning exercise on nitric oxide and antioxidants in hippocampus of epileptic seizure.
Article in Journal of exercise rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- The Potential Role of Previous Physical Exercise Program to Reduce Seizure Susceptibility: A Systematic Review and Meta-Analysis of Animal Studies.Frontiers in neurology · 2021Pooled it
- Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences.International journal of molecular sciences · 2022Article
- Physical Activity vs. Redox Balance in the Brain: Brain Health, Aging and Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Combination Therapy With Polydeoxyribonucleotide and Pirfenidone Alleviates Symptoms of Acute Respiratory Distress Syndrome in Human Lung Epithelial A549 Cells.International neurourology journal · 2020Article
- Neuroprotective effects ofAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of epileptic seizure has not been identified clearly. Exercise can play a role of antioxidants against oxidative stress. In the present study, the neuroprotective effects of preconditioning exercise on epileptic seizure were investigated with focusing on antioxidants activity in the hippocampus. Rats were allocated to the following groups: saline control group, kainic acid control group, and previous exercise and kainic acid group. Rats in the previous exercise and kainic acid group were subjected to treadmill exercise 5 days a week for 4 weeks. After 48 hr of exercise period, rats in the kainic acid control group and previous exercise and kainic acid group were injected with kainic acid. The number of neuronal nitric oxide synthase-positive cells and the level of nitrite in hippocampus were increased and the expressions of superoxide dismutase-1, superoxide dismutase-2, and catalase in hippocampus were reduced in kainic acid control group compared with saline control group. By contrast, in the previous exercise and kainic acid group, the number of neuronal nitric oxide synthase-positive cells and the level of nitrite were decreased and the expressions of superoxide dismutase-1, superoxide dismutase-2, and catalase were increased compared with the kainic acid control group. Preconditioning exercise may have neuroprotective effects against oxidative stress via increased antioxidant activity in the hippocampus of epileptic seizure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.