Evidence map›Paper›PMID 31938646›Full record

ArticleCureus2019

Dosimetric Feasibility of Utilizing the ViewRay Magnetic Resonance Guided Linac System for Image-guided Spine Stereotactic Body Radiation Therapy.

Gage Redler, Tynan Stevens, Jochen Cammin, Martha Malin, Olga Green, Sasa Mutic, Sean Pitroda, Bulent Aydogan

Open access · diamondAbstract read
In one paragraph

Article in Cureus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Gage RedlerRadiation Oncology, Moffitt Cancer Center, Tampa, USA.
Tynan StevensMedical Physics, Dalhousie University, Halifax, CAN.
Jochen CamminRadiation Oncology, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, USA.
Martha MalinRadiation Oncology, New York University, Langone Medical Center & Laura and Issac Perlmutter Cancer Center, New York, USA.
Olga GreenRadiation Oncology, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, USA.
Sasa MuticRadiation Oncology, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, USA.
Sean PitrodaRadiation and Cellular Oncology, University of Chicago, Chicago, USA.
Bulent AydoganRadiation and Cellular Oncology, University of Chicago, Chicago, USA.
Jewish Hospital · USMoffitt Cancer Center · USBarnes-Jewish Hospital · USDalhousie University · CAUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSpine stereotactic body radiation therapy (SBRT) achieves favorable outcomes compared to conventional radiotherapy doses/fractionation. The spinal cord is the principal dose-limiting organ-at-risk (OAR), and safe treatment requires precise immobilization/localization. Therefore, image guidance is paramount to successful spine SBRT. Conventional X-ray imaging and alignment to surrogate bony anatomy may be inadequate, whereas magnetic resonance imaging (MRI) directly visualizes the dose-limiting cord. This work assessed the dosimetric capability of the ViewRay (ViewRay Inc. Oakwood Village, OH) magnetic resonance (MR) guided linac (MR-Linac) for spine SBRT.

methodsEight spine SBRT patients without orthopedic hardware who were previously treated on a TrueBeam using volumetric modulated arc therapy (VMAT) were re-planned using MR-Linac fixed-field intensity-modulated radiation therapy (IMRT). Phantom measurements using film, ionization chamber, and a commercial diode-array assessed feasibility. Plans included a variety of prescriptions (30-50 Gy in 3-10 fractions).

resultsMR-Linac plans satisfied all clinical goals. Compared to VMAT plans, both entrance dose and heterogeneity increased (D

conclusionSpine SBRT with the MR-Linac is feasible as verified via re-planning eight clinical cases followed by delivery verification in phantoms using film, diodes, and an ionization chamber. Real-time visualization of the dose-limiting cord during spine SBRT may enable cord-based gating, reduced margins, alternate dose schemas, and/or adaptive therapy.

Indexed as

dosimetry treatment planningigrtmagnetic resonance-guided radiation therapy (mrgrt)mr-igrtspine sbrt

Identifiers

PMID31938646
PMCPMC6957030
OpenAlexW2995636640

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.