ReviewCancers of the head & neck2020
Adaptive radiotherapy for head and neck cancer.
Review in Cancers of the head & neck, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Deep learning methods for enhancing cone-beam CT image quality toward adaptive radiation therapy: A systematic review.Medical physics · 2022Pooled it
- HyperSight CBCT dose calculation accuracy for adaptive head and neck radiotherapy: Results from a prospective clinical trial.Medical physics · 2026Trial
- Impact of daily adaptive head and neck radiotherapy on toxicity and quality of life: results of the DARTBOARD phase II randomized trial.Journal of the National Cancer Institute · 2025Trial
- HyperSight CBCT image quality and metal artifact reduction for adaptive head and neck radiotherapy: Results from a prospective clinical trial.Journal of applied clinical medical physics · 2025Trial
- Assessment of clinical radiosensitivity in patients with head-neck squamous cell carcinoma from pre-treatment quantitative ultrasound radiomics.Scientific reports · 2021Trial
- Adaptive 3D-CRT with CCRT for head and neck cancer: resource limited single center experience in Bangladesh.Radiological physics and technology · 2026Article
- Towards a clinically practical computational platform for systematically adapting radiation therapy for glioma patients.Physics in medicine and biology · 2026Article
- Early Salivary Gland Shrinkage Is Associated With an Increased Risk of Acute Xerostomia in Head and Neck Cancer Radiation Therapy.Advances in radiation oncology · 2026Article
- Evaluating synthetic CT from deformable registration in directed adaptive radiotherapy for head and neck cancer.Journal of applied clinical medical physics · 2026Article
- Daily adaptive radiotherapy in head and neck squamous cell carcinoma can negatively impact organ at risk dosimetry.Clinical and translational radiation oncology · 2026Article
- Performance of a Vendor System for Systematic Offline Adaptive Breast Helical Radiotherapy.Cancers · 2026Article
- Imaging Biomarkers in Radiotherapy.Cancers · 2026Review
- Evaluation of deformable image registration vs offline adaptive replanning in post-op oral cavity cancer treated with volumetric modulated Arc therapy.Scientific reports · 2026Article
- Margins of Planning Target Volume and Set-up Errors based on Megavoltage Cone-Beam CT Image Guided Radiotherapy with Helical Tomotherapy: Importance of Automatic Registration Plus Manual Registration.Journal of biomedical physics & engineering · 2026Article
- Tolerability and efficacy of simultaneously integrated boost radiotherapy in head and neck cancer treatment.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026Article
- Patterns of response in head and neck cancer subregions using daily Quantitative MRI from MR-guided radiation therapy.Clinical and translational radiation oncology · 2026Article
- Factors requiring adaptive re-planning in carbon ion radiotherapy for head and neck cancers.Frontiers in oncology · 2026Article
- Quantification of head and neck cancer patients' anatomical changes during radiotherapy: Toward the prediction of replanning need.Journal of applied clinical medical physics · 2026Article
- Dosimetric evaluation of synthetic kilo-voltage CT images generated from megavoltage CT for head and neck tomotherapy using a conditional GAN network.Physical and engineering sciences in medicine · 2025Article
- Beyond Standard Radiotherapy: an AI-Driven Framework for Personalized Radiotherapy with a Four-Step Classification in Head and Neck Squamous Cell Carcinoma (HNSCC) Patients.Current oncology reports · 2025Review
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough there have been dramatic improvements in radiotherapy for head and neck squamous cell carcinoma (HNSCC), including robust intensity modulation and daily image guidance, these advances are not able to account for inherent structural and spatial changes that may occur during treatment. Many sources have reported volume reductions in the primary target, nodal volumes, and parotid glands over treatment, which may result in unintended dosimetric changes affecting the side effect profile and even efficacy of the treatment. Adaptive radiotherapy (ART) is an exciting treatment paradigm that has been developed to directly adjust for these changes. MAIN BODY: Adaptive radiotherapy may be divided into two categories: anatomy-adapted (A-ART) and response-adapted ART (R-ART). Anatomy-adapted ART is the process of re-planning patients based on structural and spatial changes occurring over treatment, with the intent of reducing overdosage of sensitive structures such as the parotids, improving dose homogeneity, and preserving coverage of the target. In contrast, response-adapted ART is the process of re-planning patients based on response to treatment, such that the target and/or dose changes as a function of interim imaging during treatment, with the intent of dose escalating persistent disease and/or de-escalating surrounding normal tissue. The impact of R-ART on local control and toxicity outcomes is actively being investigated in several currently accruing trials.
conclusionsAnatomy-adapted ART is a promising modality to improve rates of xerostomia and coverage in individuals who experience significant volumetric changes during radiation, while R-ART is currently being studied to assess its utility in either dose escalation of radioresistant disease, or de-intensification of surrounding normal tissue following treatment response. In this paper, we will review the existing literature and recent advances regarding A-ART and R-ART.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.