ArticleACS medicinal chemistry letters2020
In-Line Purification: A Key Component to Facilitate Drug Synthesis and Process Development in Medicinal Chemistry.
Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Antiviral drug discovery and development: challenges and future directions.Signal transduction and targeted therapy · 2026Review
- Review
- Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve?Journal of medicinal chemistry · 2025Review
- A Coalescing Filter for Liquid-Liquid Separation and Multistage Extraction in Continuous-Flow Chemistry.Organic process research & development · 2024Article
- From monomer to micelle: a facile approach to the multi-step synthesis of block copolymersChemical science · 2023Article
- Continuous flow synthesis of pyridinium salts accelerated by multi-objective Bayesian optimization with active learning.Chemical science · 2023Article
- Determining Phase Separation Dynamics with an Automated Image Processing Algorithm.Organic process research & development · 2023Review
- Towards Antibiotic Synthesis in Continuous-Flow Processes.Molecules (Basel, Switzerland) · 2023Review
- Flow synthesis of oxadiazoles coupled with sequential in-line extraction and chromatography.Beilstein journal of organic chemistry · 2022Article
- Continuous Flow Synthesis of Anticancer Drugs.Molecules (Basel, Switzerland) · 2021Review
- Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives.Beilstein journal of organic chemistry · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In-line purification is an important tool for flow chemistry. It enables effective handling of unstable intermediates and integration of multiple synthetic steps. The integrated flow synthesis is useful for drug synthesis and process development in medicinal chemistry. In this article, we overview current states of in-line purification methods. In particular, we focus on four common methods: scavenger column, distillation, nanofiltration, and extraction. Examples of their applications are provided.
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Registered trials
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