ArticleInternational journal of clinical and experimental pathology2018
The role of Keap1-Nrf2-ARE signal pathway in diabetic retinopathy oxidative stress and related mechanisms.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Targeting of Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) Signaling Pathway in Age-Related Eye Diseases: Molecular Mechanisms and Opportunities for therapy.Journal of biochemical and molecular toxicology · 2026Review
- Resveratrol as a Novel Therapeutic Approach for Diabetic Retinopathy: Molecular Mechanisms, Clinical Potential, and Future Challenges.Molecules (Basel, Switzerland) · 2025Review
- Retinal Penetrating Adeno-Associated Virus.Investigative ophthalmology & visual science · 2024Article
- Biochemical Changes in Anterior Chamber of the Eye in Diabetic Patients-A Review.Journal of clinical medicine · 2024Review
- Protective Effect and Related Mechanism of Modified Danggui Buxue Decoction on Retinal Oxidative Damage in Mice based on Network Pharmacology.Current pharmaceutical design · 2024Article
- Evidence of Nrf2/Keap1 Signaling Regulation by Mitochodria-Generated Reactive Oxygen Species in RGK1 Cells.Biomolecules · 2023Article
- Study on the Antioxidant Effect of Tanshinone IIA on Diabetic Retinopathy and Its Mechanism Based on Integrated Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Oxidative stress parameters and keap 1 variants in T2DM: Association with T2DM, diabetic neuropathy, diabetic retinopathy, and obesity.Journal of clinical laboratory analysis · 2022Article
- Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues.Antioxidants (Basel, Switzerland) · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDiabetic retinopathy (DR) is one severe complication of diabetes, and involves reactive oxygen species (ROS) produced under oxidative stress (OS) conditions. Keap1-Nrf2-ARE is one important endogenous anti-OS signal pathway. This study generated a type 2 DR rat model, on which expression of Nrf2/ARE pathway related proteins were measured to investigate functional role and mechanism of Keap1-Nrf2-ARE signal pathway in DR. PATIENTS AND
methodsUsing DR model rats, blood samples were collected for measuring FBG, TC, TG, HDL-C, and LDL-C for evaluating blood glucose and lipid. Retinas were collected for measuring ROS content using DCFH-DA staining, and caspase-3 activity was measured by colorimetry. Cell apoptosis was measured by flow cytometry. Keap1 and Nrf2 proteins were quantified by Western blot. Aqueous humor was collected for measuring MDA, SOD, GSH-Px, and T-AOC.
resultsModel rats had significantly elevated blood FBG, TG, TC, and LDL-C, plus decreased HDL-C. Model rats also had higher retinal ROS content, enhanced caspase-3 activity, and potentiated apoptosis. Compared to the control group, model rats had elevated MDA and lower activity of SOD, GSH-Px, and T-AOC in aqueous humor, plus lower Keap1 and higher Nrf2 expression in retina.
conclusionDR rats showed significantly elevated retinal apoptosis, with prominent OS. Under diabetic conditions, activation of Keap1-Nrf2-ARE pathway may play a role in alleviating OS damage and protecting retina.
Indexed as
Identifiers
31938435PMC6958062W3011099182What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.