Evidence map›Paper›PMID 31938384›Full record

ArticleInternational journal of clinical and experimental pathology2018

Low expression of trafficking protein particle complex 4 predicts poor prognosis in hepatocellular carcinoma.

Jian-Dong Shen, Xin-Feng Cai, Jue Wei, Chun-Yan Gu, Lin-Ling Ju, Yi-Fang Wang, Feng Dai, Shou-Zhong Fu, Zhao-Lian Bian, Long-Ju Qi

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jian-Dong ShenDepartment of Invasive Technology, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Xin-Feng CaiDepartment of Liver and Gallbladder Surgery, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Jue WeiDepartment of Gastroenterology, Tongren Hospital, Shanghai Jiaotong University School of Medicine Shanghai, China.
Chun-Yan GuDepartment of Pathology, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Lin-Ling JuNantong Institute of Liver Diseases, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Yi-Fang WangNantong Institute of Liver Diseases, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Feng DaiDepartment of Invasive Technology, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Shou-Zhong FuDepartment of Invasive Technology, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Zhao-Lian BianNantong Institute of Liver Diseases, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Long-Ju QiDepartment of Invasive Technology, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Nantong University · CNTongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Tumor recurrence and metastasis are major factors that contribute to the poor outcome of patients with HCC. However, it is difficult to predict the prognosis of hepatocellular carcinoma. Trafficking Protein Particle Complex 4 (Trappc4), is associated with tumorigenesis. The present study aimed to detect Trappc4 expression in HCC and its association with clinicopathological patient data. More importantly, this study reveals the relationship between Trappc4 and the prognosis of hepatocellular carcinoma. A total of 148 HCC tissues were assessed for expression of Trappc4 mRNA and protein with (reverse transcription polymerase chain reaction) RT-PCR (n=36), Western blotting (n=4) and immunohistochemistry (n=148), respectively. The data show that Trappc4 mRNA and protein are expressed at low levels in HCC tissues compared to adjacent tissues. Immunohistochemical analysis revealed that 148 cases of HCC showed different degrees of positive expression. Statistical analysis showed that expression of Trappc4 was associated with histological differentiation, TNM stage, and vascular invasion (

Indexed as

biomarkerhepatocellular carcinomaprognosisTrafficking protein particle complex 4

Identifiers

PMID31938384
PMCPMC6958281
OpenAlexW3028352794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.