ArticleInternational journal of clinical and experimental pathology2018
High concordance of EGFR mutation status between sputum and corresponding tissue specimens of late-stage lung cancers using amplification refractory mutation system-PCR.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Sputum Liquid Biopsy for Lung Cancer Screening, Diagnosis, Subtyping, Surveillance, Response Prediction, and Prognostication: A Scoping Review.Medical sciences (Basel, Switzerland) · 2026Article
- Molecular switch-mediated detection ofBioengineering & translational medicine · 2026Article
- Seasonal impact of PMScientific reports · 2025Article
- Article
- Detection of EGFR mutation of pulmonary adenocarcinoma in sputum using droplet digital PCR.BMC pulmonary medicine · 2021Article
- Detection of EGFR Activating and Resistance Mutations by Droplet Digital PCR in Sputum of EGFR-Mutated NSCLC Patients.Clinical Medicine Insights. Oncology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
backgroundTo gain sufficient tumor tissue for EGFR mutations analysis is of prime clinical importance. Therefore, the objective of present study was to assess whether sputum is suitable for EGFR testing and to assess the consistency between sputum and tissue specimens.
methodsThis analysis included 37 paired sputum and tissue specimens obtained from late-stage lung cancer patients followed by EGFR analysis using the ARSM-PCR method, and 11 sputum specimens of COPD were added as negative control.
results35 out of 37 (94.6%) patients with lung cancer were found to have tumor cells in the sputum specimen using the LCT method and extracted adequate DNA for EGFR testing. In contrast, only five out of 11 cases of COPD (45.5%) were isolated with sufficient DNA (
conclusionsThe findings of the current study suggest a high concordance between sputum and tissue specimens, reflecting the important potential of sputum specimens for EGFR mutant detection in patients with late-stage lung cancer using the ARSM-PCR method.
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31938383PMC6958240What OpenQuestion holds
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