Overexpression of particularly interesting new cys-his rich protein (PINCH) is a risk factor for growth of unruptured intracranial aneurysms.

Wei Li, Lin Ma, Chao Tian

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 77% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wei LiDepartment of Ultrasonography, Tianjin Huanhu Hospital Tianjin 300350, China.

Lin MaDepartment of Neurosurgery, Tianjin Huanhu Hospital Tianjin 300350, China.

Chao TianDepartment of Medical Imaging, Tianjin Huanhu Hospital Tianjin 300350, China.

Tianjin Huanhu Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Particularly interesting new cys-his rich protein (PINCH), as an adaptor protein, regulates matrix deposition, cell proliferation, invasion, and metastasis. PINCH plays an important role for tumorigenesis and progression. However, the contributions of PINCH to intracranial aneurysms (IA) remain largely unknown. In our study, we demonstrated that PINCH expression was significantly increased in IA samples compared with healthy controls. The size of IA had a remarkable correlation with PINCH expression. However, PINCH expression had no obvious difference among different Hunt-Hess grades. In addition, the expressions of MMP-2 and MMP-9 were significantly increased in IA tissues compared with healthy controls; moreover, PINCH expression in IA tissues was significantly correlated with MMP-2 and MMP-9 expression. In conclusion, these results suggest that PINCH might play a role similar to MMP-2 and MMP-9 in the pathogenesis of IA. PINCH might be a risk factor for growth of unruptured IA, and this might be a target for diagnosis and therapy of IA.

Indexed as

intracranial aneurysmsMMP-2MMP-9Particularly interesting new cys-his rich proteinprognosis

Identifiers

PMID31938378

PMCPMC6958234

OpenAlexW3026104635

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.