ArticleInternational journal of clinical and experimental pathology2018
Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Gut-Brain Inflammation and Disrupted Homeostasis Due to Activation of Mast Cells and Microglia.International journal of molecular sciences · 2026Review
- Integrated metagenomics and transcriptomics analysis reveals pathways associated with oral periapical lesions formation and progression.Current research in microbial sciences · 2025Article
- Inflammatory mediators' essence in apical periodontitis.European oral research · 2024Article
- Article
- The Remodeling of Dermal Collagen Fibrous Structures in Mice under Zero Gravity: The Role of Mast Cells.International journal of molecular sciences · 2023Article
- The Paradigm of the Inflammatory Radicular Cyst: Biological Aspects to be Considered.European endodontic journal · 2023Review
- Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis.Frontiers in cellular and infection microbiology · 2022Review
- Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment.BMC oral health · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to detect the expression of matrix metalloproteinase-8 (MMP-8) and MMP-13 in mast cells (MCs) of human periapical lesions and to discuss the pathogenic role of MCs in periapical lesions.
methodsNinety samples were divided into three groups: (1) periapical granuloma group (n=30); (2) periapical cyst group (n=30); (3) normal periodontal membrane group (n=30). The samples were fixed in 10% neutral formalin for over 48 h and made into serial sections. After H&E staining, histological changes were observed under the optical microscope. Moreover, double immunofluorescence (DIF) staining was performed to detect expression of MMP-8 and MMP-13 in MCs of periapical lesions under the fluorescence microscope.
resultsCompared with the normal control group, the number of MMP-8 and MMP-13 double positive MCs in the periapical lesions increased significantly (P<0.01). There was no significant difference in the density of MMP-8 and MMP-13 double positive MCs in the periapical cyst group and periapical granuloma group (P>0.05).
conclusionThe number of MCs increased significantly in periapical lesions and there was a considerable increase in the density of MMP-8 and MMP-13 double positive MCs. These results indicate that MCs positive for MMP-8 and MMP-13 might contribute to the pathogenesis of chronic apical periodontitis.
Indexed as
Identifiers
31938366PMC6958287W3011295554What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.